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    • CONTACT

PURECIUM

  • HOME
  • PURECIUM
  • INGREDIENTS
  • NEWS
  • CUSTOMIZED
  • QUALITY CONTROL
  • CONTACT
  • …  
    • HOME
    • PURECIUM
    • INGREDIENTS
    • NEWS
    • CUSTOMIZED
    • QUALITY CONTROL
    • CONTACT
  • PURECIUM

    PURE BY NATURE

    Embodies the essence of pure, high-quality dietary supplement ingredients

  • BERBERINE HCL

    Supports a Healthy Metabolism & Gut

    Berberine hcl

    BERBERINE HCL

    Unlock the benefits of Berberine HCL, a powerful botanical extract celebrated for its role in metabolic health. Sourced from plants, this natural compound is scientifically shown to help manage blood sugar levels already within the normal range. It also supports a healthy gut microbiome, aids in maintaining healthy cholesterol levels, and helps balance metabolism, making it an excellent addition to your daily wellness routine.

    Product name: Berberine hcl

    Molecular formula: C₂₀H₁₈ClNO₄・2H₂O

    Starting material: Homopiperony lamine/Berberis aristata

    Grade: Food grade

    Heavy Metals: USP/EP

    Pesticide residue: USP/EP

    Packing size: 25kg/drum

    CAS#: 633-65-8

    Molecular weight:407.85 g/mol

    Source: Synthetic/Natural

    Specification: 98%/97% HPLC

    Country of origin: China

    Residual solvent: USP/EP

    Allergen free/Gluten-free/Non-GMO/Vegan/Non-Irridiation

    ISO, Kosher, halal, food safety certification

    Berberine hydrochloride, a widely - used alkaloid in the pharmaceutical and health - care industries, is mainly sourced from plants such as Coptis chinensis, Phellodendron amurense, Berberis species (San Ke Zhen in Chinese), and Daemonorops jenkinsiana. These plants are predominantly distributed in Southeast Asia, with a high concentration in countries like China, India, Myanmar, and Cambodia.​

    Coptis chinensis, known for its high berberine content, has been listed as an endangered plant in China. Phellodendron amurense, another important source, is also under protection in China due to over - exploitation. As a result, currently, the main natural sources of berberine hydrochloride are Berberis species and Daemonorops jenkinsiana. Berberis species are widely distributed in mountainous areas, and their roots and stems contain a significant amount of berberine. Daemonorops jenkinsiana, which is rich in this alkaloid, grows in specific tropical and subtropical regions.

    ​

    Back in the 1950s, synthetic berberine started to be mass - produced. Synthetic berberine provides a stable supply, reducing the heavy reliance on natural plant resources. This not only helps to protect the endangered plant species but also meets the growing market demand for berberine hydrochloride in various fields, including medicine, food additives, and dietary supplements. The production of synthetic berberine has been optimized over the years, with continuous improvement in yield and quality, making it a reliable alternative to the natural product.

    ​

    In conclusion, while natural sources like Berberis species and Daemonorops jenkinsiana still play a role, synthetic berberine has become an increasingly important part of the market supply, ensuring the availability of this valuable ingredient while contributing to environmental protection.

    Berberine, a natural compound, offers a range of health benefits.

    ​

    Firstly, it has remarkable antibacterial properties. It can effectively inhibit the growth of various bacteria like Escherichia coli and Staphylococcus aureus, playing a significant role in treating infectious diseases, especially those in the digestive tract such as bacterial gastroenteritis and dysentery.

    ​

    Secondly, berberine shows anti - inflammatory effects. By reducing the production of inflammatory mediators, it helps alleviate inflammation in the body, which is beneficial for conditions like arthritis and inflammatory bowel diseases.​

    Moreover, it is known to have a positive impact on metabolism. Berberine can improve insulin sensitivity, thus assisting in blood sugar control for diabetes patients. It also helps manage cholesterol levels by lowering LDL cholesterol and triglycerides while increasing HDL cholesterol, contributing to better cardiovascular health.

    Berberine has long been recognized for its antiviral properties, especially in treating diarrhea. In the past two years, research has shown that it also has significant functions in weight loss and blood sugar reduction. These newly - discovered benefits have led to a sharp increase in the market demand for berberine.

    ​

    Traditionally, berberine was mainly extracted from plants such as Coptis chinensis, Phellodendron amurense, Berberis species, and Daemonorops jenkinsiana, which are mainly distributed in Southeast Asia, with a large quantity in countries like China, India, Myanmar, and Cambodia. However, Coptis chinensis and Phellodendron amurense have been listed as endangered plants in China. As a result, the natural resources for berberine extraction are becoming scarce and cannot meet the growing market demand.

    ​

    Consequently, an increasing number of customers are turning to synthetic berberine as a substitute. But the raw materials used in the synthesis of berberine are substances related to drug - making, and their production is strictly regulated in China. This regulatory measure has led to a continuous increase in the price of berberine, and there have even been shortages in the market.

    ​

    Nevertheless, as a large number of synthetic manufacturers have entered the market, the production capacity of synthetic berberine has been gradually released, causing the price to decline gradually. On the other hand, due to the cost constraints of raw materials for naturally - extracted berberine, its price only fluctuates within a small range and is less affected by market changes. In conclusion, the berberine market is experiencing a complex situation of supply, demand, and price changes, which requires continuous attention from both producers and consumers.

  • Berberine hcl
    Berberine hcl
    Berberine hcl
    Berberine hcl
    Berberine hcl
    Berberine hcl
  • Berberine HCL Frequently Asked Questions (FAQ)

    1. What does Berberine Hcl look like?

    Berberine Hcl is a fine yellow powder/granular.

    2. Do you sell finished Berberine Hcl products?

    We do not sell finished products. We only supply raw ingredients. However, we can partner with a contract manufacturer to provide white-label services, including tablets, hard capsules, soft capsules, and gummies.

    3. Do you sell Berberine Hcl to individual customers?

    Unfortunately, we do not sell our products to individual customers. Our target clientele includes distributors, contract manufacturers, and end-brand users.

    4. What is the MOQ and price for your Berberine Hcl?

    Our MOQ is 25 kg. For detailed pricing, please contact our sales team at info@purecium.com.

    5. How can I purchase your Berberine Hcl?

    For customers in the United States, Canada, and Mexico, pickup is available from our U.S. warehouse. We can also arrange for door-to-door delivery in these regions. For all other regions, orders will be shipped from China.

    6. What is the delivery time?

    Pickup from our U.S. warehouse is available within 2 days after the order is placed. Shipments from China are delivered within one week of the order being placed.

    7. What are the main forms of finished Berberine Hcl products?

    Common forms include tablets, hard capsules or softgel.

    8. What is the difference between synthetic and natural Berberine hcl?

    The main difference lies in their origin. Synthetic Berberine Hcl is generally more cost-effective than natural.

    9. What is the source of Synthetic Berberine Hcl?

    The starting material for synthetic are o-Vanillin and Homopiperony lamine.

    10. What is the main plan sources of natural Berberine Hcl?

    Berberis Aristata/Berberis soulieana.

    11. How can I distinguish between natural and synthetic Berberine hcl?

    This can be determined through C14 testing or HPTLC ID testing. Natural Berberine Hcl has a bio-based carbon content of over 97%, while synthetic Berberine Hcl has a very low bio-based carbon ratio.

    12. Can you provide a C14 test report for Berberine Hcl?

    Yes, we can. Please contact our sales team at info@purecium.com to request the relevant report.

    13. What certifications can you provide for your Berberine Hcl?

    We can provide the following certifications: ISO9001, Kosher, Halal, and FSSC22000.

    14. What's the packing size of Berberine Hcl?

    Packing size: 25kg/drum.

    Drum size: 40cm*40cm*50cm.

    Net/Gross weight: 25/28 kg.

    15. What are the storage conditions and shelf life for Berberine Hcl?

    Please store it in a tightly sealed, dry place, away from light. The shelf life is 24 months.

    16. Can you provide a stability report for Berberine Hcl?

    Yes, we can provide data from both accelerated and long-term stability tests. Please contact our sales team at info@purecium.com to obtain the reports.

    17. Is the supply of Berberine Hcl stable? What is your production capacity?

    Yes, we can ensure a consistent, long-term supply. Synthetic Berberine Hcl has a designed capacity of 500 MT/year, while natural Berberine Hcl has a designed capacity of 300 MT/year.

    18. What is the mesh size of your Berberine Hcl?

    Standard Berberine Hcl is a 80 mesh powder. We can also supply a 20-60 mesh granular, which is suitable for direct use in capsule filling or tableting.

    19. Why is berberine so popular in the global market?

    Berberine has a long history of use in China, where it was initially used to treat diarrhea and intestinal diseases due to its unique antibacterial properties since the 1950s. In recent years, due to clinical trials demonstrating the positive effects of Berberine HCL on weight loss and blood sugar management, market demand has surged significantly.

    20. Why has natural berberine been in short supply?

    Natural berberine has historically faced supply shortages because its traditional plant sources—coptis and phellodendron—are harvested from the rhizome and bark, which is a destructive process for the plants. Consequently, these species were listed as endangered. There has been a subsequent shift toward using barberry as a more sustainable natural source.

    21. What's the difference between natural and synthetic on the testing method?

    Natural berberine hydrochloride is typically analyzed using a titration method, which confirms a content of not less than 97%.In contrast, synthetic berberine hydrochloride is generally tested with HPLC (High-Performance Liquid Chromatography), which ensures a content of not less than 98%.

    22. How would you describe the water solubility of berberine hydrochloride?

    Berberine hydrochloride (Berberine HCL) is considered sparingly soluble in water. This means it will dissolve, but its solubility is relatively low. As a result, when formulating products or solutions, measures such as heating, agitation, or using a co-solvent are often needed to help it dissolve more effectively.

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PURECIUM LIMITED

Address: Room 509, The cloud 111 Tung chua ST, Tai kok TSUI, HONG KONG.

Global network:

Hong Kong|Mainland China

US: California| New York

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