• PURECIUM

    PURE BY NATURE

    Embodies the essence of pure, high-quality dietary supplement ingredients

  • BHB(BETA-HYDROXYBUTYRATE)

    The second-generation L-Carnitine

    BHB-Betahydroxybutyrate

    BHB-Betahydroxybutyrate

    Beta-hydroxybutyrate (BHB) is a key ketone body produced by the liver, essential for providing energy when carbohydrates are not available. As a popular ingredient in ketogenic supplements, our BHB salt powder helps elevate blood ketone levels, offering a clean and efficient fuel source for both the brain and muscles. We ensure a stable, high-quality B2B supply, allowing your brand to meet the growing demand for metabolic support products.

    Product name: BHB(Beta-hydroxybutyrate)

    Molecular formula: C4​H8​O3​

    Starting material: Ethyl acetoacetate

    Grade: Food grade

    Heavy Metals: USP/EP

    Pesticide residue: USP/EP

    Packing size: 20/25 kg/drum

    Product available:

    • Calcium BHB(Beta-hydroxybutyrate)(DL)
    • Magnesium BHB(Beta-hydroxybutyrate)(DL)
    • Sodium BHB(Beta-hydroxybutyrate)(DL)
    • Potassium BHB(Beta-hydroxybutyrate)(DL)
    • Calcium BHB(Beta-hydroxybutyrate)(D)
    • Magnesium BHB(Beta-hydroxybutyrate)(D)
    • Sodium BHB(Beta-hydroxybutyrate)(D)
    • Potassium BHB(Beta-hydroxybutyrate)(D)

    CAS#: 625-72-9

    Molecular weight: 104.105 g/mol

    Source: Synthetic

    Specification: 98% HPLC

    Country of origin: China

    Residual solvent: USP/EP

    Allergen free/Gluten-free/Non-GMO/Vegan/Non-Irridiation

    BHB ISO, Kosher, halal, food safety certification

    BHB, short for β-hydroxybutyrate, is a natural ketone body found in the human body and is a by-product of fat metabolism.

    BHB is one of the main ketone bodies, primarily produced in the liver through the breakdown of fats. When the body is in a state of hunger, following a low-carbohydrate diet, or undergoing prolonged exercise, and the supply of glucose is insufficient, BHB can serve as an alternative energy source for the heart, skeletal muscles, and the brain. It can cross the blood-brain barrier, providing energy for brain cells and influencing neuron activity through regulating specific receptors and enzyme systems.

    Chemically, BHB has the molecular formula C4H8O3, a molecular weight of approximately 104.105, and a CAS number of 625 - 72 - 9. In addition to its role as an energy source, BHB also has anti-inflammatory and antioxidant properties, which can reduce inflammatory responses and have a positive impact on cellular antioxidant stress.

    Furthermore, BHB is involved in the regulation of glucose and fat metabolism. When blood sugar levels drop, the production of BHB increases, helping to maintain blood sugar stability and prompting the body to use fat as an energy source.

    BHB (β-hydroxybutyrate) has been commercialized into various product forms to cater to diverse consumer needs in the health, fitness, and wellness sectors. Here are the key commercial product categories:

    1. Ketone Salts (BHB Salts)

    The most common form is BHB salts, including sodium, potassium, magnesium, and calcium salts. These are typically sold as powders or capsules for easy oral administration. These salts are popular in sports nutrition due to their ability to boost endurance and aid muscle recovery, with market reports indicating significant growth in this segment. Mixed BHB salts (e.g., combining sodium and potassium) are also available to balance electrolyte levels during ketosis.

    2. Ketone Esters (BHB Esters)

    Ketone esters are synthetic compounds that directly supply BHB without requiring metabolic conversion. These are often formulated into ready-to-drink (RTD) beverages or powdered mixes for rapid energy delivery

    3. Liquid BHB Supplements

    Liquid BHB products are an additive-free solution for quick ketone absorption. These are designed for keto-adapted users who prefer minimal ingredients and a tart taste, avoiding sweeteners or flavors that might disrupt ketosis. Liquid forms are often recommended for post-carbohydrate binges to re-enter ketosis rapidly or as a pre-workout boost.

    The primary market for BHB (β-hydroxybutyrate) lies in North America, mainly the United States and Canada, which account for approximately 50% of the global consumption volume. This dominant position is driven by factors such as the widespread adoption of ketogenic diets for weight management and sports performance, a well-developed dietary supplement industry, and high consumer awareness of metabolic health benefits associated with BHB. Major brands in the region have established strong distribution networks across retail stores and e-commerce platforms, further solidifying North America’s leading role in the global BHB market.

    Europe, despite facing relatively strict regulatory oversight currently, represents a market with significant future growth potential. Stringent regulations related to product labeling, safety claims, and ingredient approval have temporarily slowed market expansion in some European countries. However, as regulatory frameworks become more clear and standardized, and with growing consumer interest in low-carb and metabolic health solutions, the region is expected to witness accelerated growth in BHB adoption in the coming years.

    Additionally, other emerging markets such as the United Kingdom, South Africa, and Brazil are experiencing robust growth momentum. In these regions, rising health consciousness, increasing prevalence of lifestyle-related health concerns, and the expansion of e-commerce channels have fueled demand for BHB products. The growing popularity of ketogenic and low-carb diets among fitness enthusiasts and health-focused consumers is also contributing to the rapid development of the BHB market in these emerging economies.

  • Beta-hydroxybutyrate (BHB)
    Beta-hydroxybutyrate (BHB)
    Beta-hydroxybutyrate (BHB)
    Beta-hydroxybutyrate (BHB)
    Beta-hydroxybutyrate (BHB)
    Beta-hydroxybutyrate (BHB)

  • BHB(Beta-hydroxybutyrate) Frequently Asked Questions (FAQ)

    1. Do you sell finished BHB (β-hydroxybutyrate) products?

    We do not sell finished products. We only supply raw ingredients. However, we can partner with a contract manufacturer to provide white-label services, including tablets, hard capsules, and soft capsules.

    2. Do you sell BHB (β-hydroxybutyrate) to individual customers?

    Unfortunately, we do not sell our products to individual customers. Our target clientele includes distributors, contract manufacturers, and end-brand users.

    3. What is the MOQ and price for your BHB (β-hydroxybutyrate)?

    Our MOQ is 20/25 kg. For detailed pricing, please contact our sales team at info@purecium.com.

    4. How can I purchase your BHB (β-hydroxybutyrate)?

    For customers in the United States, Canada, and Mexico, pickup is available from our U.S. warehouse. We can also arrange for door-to-door delivery in these regions. For all other regions, orders will be shipped from China.

    5. What is the delivery time?

    Pickup from our U.S. warehouse is available within 2 days after the order is placed. Shipments from China are delivered within one week of the order being placed.

    6. What are the main forms of finished BHB (β-hydroxybutyrate) products?

    Common forms include hard capsules and beverages.

    7. Which solvents are used in the production process of BHB (β-hydroxybutyrate)?

    Food-grade anhydrous ethanol and isopropanol are used, with residual levels controlled to within 5,000 ppm, in accordance with USP standards.

    8. What are the heavy metal limits in finished BHB (β-hydroxybutyrate) products?

    According to EU and USP standards, the heavy metal limits for melatonin are as follows:

    Lead: < 0.5 ppm

    Mercury: < 0.1 ppm

    Arsenic: < 3 ppm

    Cadmium: < 1 ppm

    9. What certifications can you provide for your BHB (β-hydroxybutyrate)?

    We can provide the following certifications: ISO9001, Kosher, Halal, and FSSC22000.

    10. What's the packing size of BHB (β-hydroxybutyrate)?

    Packing size: 20/25kg/drum.

    Drum size: 40cm*40cm*50cm.

    Net/Gross weight: 20/23kg, 25/28 kg.

    11. What are the storage conditions and shelf life for BHB (β-hydroxybutyrate)?

    Please store it in a tightly sealed, dry place, away from light. The shelf life is 24 months.

    12. Can you provide a stability report for BHB (β-hydroxybutyrate)?

    Yes, we can provide data from both accelerated and long-term stability tests. Please contact our sales team at info@purecium.com to obtain the reports.

    13. What is the mesh size of your BHB (β-hydroxybutyrate)?

    Standard BHB (β-hydroxybutyrate) is an 80-mesh powder, and potassium BHB is a 20-mesh powder.

    14. What is the typical configuration of BHB?
    The typical BHB is in the DL configuration. Depending on the formulation, some customers may require the D configuration.

    15. What is the difference between D and L configurations of BHB?

    The D and L configurations refer to the optical properties of the molecule. Typically, DL-BHB consists of 50% D configuration and 50% L configuration. In contrast, D-BHB is 100% in the D configuration.

    • D-BHB: This is the only naturally occurring BHB isomer in the human body.
    • L-BHB: The human body cannot synthesize this isomer. Small amounts of L-BHB may be ingested through certain foods (e.g., fermented dairy products) or external supplements.

    16. What is the difference in usage between liquid and solid BHB?
    Liquid BHB is commonly used in beverages, while solid BHB is typically used in hard capsules.

    17. How should BHB be stored?
    Solid BHB is highly hygroscopic. In addition to standard sealed and light-protected storage, desiccants should be placed within the inner packaging to prevent contact with moisture in the air.

    18. What is the core mechanism of action of BHB?
    The human body typically prioritizes glucose as its primary energy source, storing fat rather than breaking it down when blood sugar is sufficient. The core mechanism of BHB is to disrupt this “glucose dependency”:

    • Inducing ketosis: When blood BHB levels reach 0.5–3 mmol/L (the ketosis threshold) through a low-carbohydrate diet, fasting, or BHB supplementation, organs such as the brain, heart, and muscles gradually switch to a “ketone-based energy mode,” reducing reliance on glucose.
    • Promoting fat breakdown: To sustain ketone body production (including BHB), the liver accelerates the breakdown of stored fat (triglycerides) into fatty acids, which are then converted into acetyl-CoA via “β-oxidation” and subsequently synthesized into BHB. This process effectively mobilizes fat reserves, directly reducing fat accumulation.
    • Inhibiting fat synthesis: BHB also suppresses the activity of key fat synthesis enzymes in the liver (e.g., acetyl-CoA carboxylase), reducing the conversion of excess carbohydrates into fat and lowering the rate of fat formation at its source.

    19. Why is BHB referred to as the second-generation L-carnitine?
    L-carnitine acts as a “fat transporter,” facilitating but not directly participating in fat metabolism. This process requires specific conditions, such as prolonged exercise of sufficient intensity, to transport fat to the mitochondria for metabolism and fat burning. In contrast, BHB directly promotes fat breakdown to produce BHB, which serves as an energy source for the body.

    20. What indicators are used to determine whether BHB is D-type or DL-type?
    The optical rotation is used to determine the configuration. The optical rotation of DL-BHB is approximately 0, while that of D-BHB ranges from -14 to -19.

    21. Is BHB a liquid or a solid?

    Pure BHB is in liquid form. For ease of transportation, storage, and formulation, it is often converted into salt forms, such as calcium, magnesium, sodium, or potassium salts. Apart from the different mineral forms, their applications are generally the same.

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