MELATONIN
For a Deeper Sleep
Melatonin
Melatonin, a natural hormone, is secreted by the pineal gland in the brain. Its production is closely tied to light exposure; it surges in the dark and drops in the light, regulating our body's circadian rhythm, the internal "clock" controlling our sleep-wake cycle. As we age, its production declines. It's also available as an over - the - counter supplement, often used to address sleep issues like insomnia and jet lag.
Product name: Melatonin
Molecular formula: C13H16N2O2
Starting material: Diethyl malonate and acrylonitrile
Grade: Food grade
Heavy Metals: USP/EP
Pesticide residue: USP/EP
Packing size: 25kg/drum
CAS#: 73-31-4
Molecular weight:232.28 g/mol
Source: Synthetic/Fermentation
Specification: 98% HPLC
Country of origin: China
Residual solvent: USP/EP
Allergen free/Gluten-free/Non-GMO/Vegan/Non-Irridiation
Melatonin is a naturally occurring substance in the human body, primarily synthesized and secreted by the pineal gland—a small, pea-sized endocrine gland located deep within the brain. Its production is closely regulated by the body’s internal circadian rhythm, with levels rising significantly in the evening as darkness falls and declining during daylight hours, playing a crucial role in regulating the sleep-wake cycle.
The main function of melatonin is to support healthy sleep patterns. By signaling to the brain that it is time to rest, it helps initiate the sleep process and improve sleep quality. For individuals with occasional sleep disturbances, such as jet lag or temporary insomnia caused by shift work or irregular schedules, melatonin can assist in adjusting the circadian rhythm to promote faster sleep onset and more restful sleep.
Unlike many synthetic sleep aids, melatonin is a hormone that the body already produces, making it a popular choice for those seeking a more natural approach to sleep support. It is important to note, however, that while melatonin is generally considered safe for short-term use, its effectiveness can vary among individuals, and consulting a healthcare professional is advisable for persistent sleep issues. Overall, melatonin serves as a key biological regulator, bridging the gap between the body’s internal clock and healthy sleep.
Currently, the majority of melatonin available on the market is primarily produced through chemical synthesis. This synthetic form has a long-standing history of use, spanning nearly a century, and has been extensively studied and proven to be safe and effective for supporting sleep. Over the decades, rigorous scientific research and clinical trials have consistently validated its ability to regulate the sleep-wake cycle, making it a widely trusted and commonly used sleep aid among consumers worldwide.
In recent years, with advancements in biotechnology and fermentation technology, melatonin derived from fermentation processes has been introduced to the market. This natural-sourced alternative offers potential advantages, such as being more aligned with the body’s natural biological processes, which has attracted attention from consumers seeking more natural health products. However, despite its promising prospects, the market share of fermented melatonin remains relatively small, mainly due to constraints in its production process and cost. The fermentation-based production route requires more complex technological conditions, stricter quality control measures, and longer production cycles compared to chemical synthesis. Additionally, the higher raw material costs and production expenses associated with fermentation result in a higher retail price for fermented melatonin, which limits its competitiveness and accessibility in the mainstream market, especially when compared to the more cost-effective synthetic counterparts.
Melatonin can be used in combination with ingredients like GABA (gamma-aminobutyric acid), magnesium, theanine, and valerian root extract to achieve synergistic effects that enhance sleep support.
GABA, the primary inhibitory neurotransmitter in the human brain, works with melatonin to calm overactive nerves. While melatonin regulates the circadian rhythm to signal sleep time, GABA directly reduces neural excitement and anxiety, helping the body transition into a relaxed state faster—ideal for those struggling to fall asleep due to stress.
Magnesium, an essential mineral, complements melatonin by maintaining nerve and muscle relaxation. A lack of magnesium often leads to restlessness or muscle tension that disrupts sleep; when paired with melatonin, it eases physical discomfort, creating a more conducive environment for melatonin to regulate the sleep-wake cycle effectively.
Theanine, an amino acid found in green tea, boosts melatonin’s benefits by promoting alpha brain waves (linked to relaxation without drowsiness). It not only helps extend deep sleep duration but also mitigates potential next-day grogginess sometimes associated with melatonin, making this pairing suitable for people needing to stay alert during the day.
Valerian root extract enhances GABA’s calming effects and lowers stress hormones like cortisol. When combined with melatonin, it strengthens long-term nerve relaxation, reducing nighttime awakenings and improving overall sleep quality.
Note that individual responses vary; starting with recommended doses and consulting a professional if taking medications is advisable.
