Q1. What is evodiamine and where does it come from?

Evodiamine is an indolequinazoline alkaloid isolated from the dried, nearly ripe fruit of Evodia rutaecarpa (Juss.) Benth., a Rutaceae plant known in traditional Chinese medicine as Wu Zhu Yu and listed botanically as Euodiae Fructus. It carries CAS 518-17-2, molecular formula C19H17N3O and molecular weight 303.36 g/mol. Purecium supplies the purified 98% crystalline form and standardized fruit extracts containing 10% to 50% evodiamine.

Q2. What purity and specification of evodiamine does Purecium supply?

Purecium supplies evodiamine at 98% minimum assay by HPLC as a white to light-yellow crystalline powder, and standardized Evodia rutaecarpa fruit extracts at 10%, 30% and 50% evodiamine by HPLC as brown powders. Each lot is tested for assay, related alkaloids (principally rutaecarpine), loss on drying, residual solvents, heavy metals, pesticide residue and microbiology, with results on the batch Certificate of Analysis.

Q3. Why is evodiamine used in thermogenic and weight-management supplements?

Peer-reviewed research describes evodiamine as an activator of TRPV1, the same receptor that mediates capsaicin's effects from chili pepper, with associated thermogenic and energy-expenditure signaling. This mechanism supports its use in thermogenic blends, typically alongside caffeine sources such as green tea extract. Preclinical data are stronger than clinical evidence, so finished-product communication should stay within structure/function language and avoid disease claims.

Q4. How is evodiamine manufactured from the botanical source?

Dried Evodia rutaecarpa fruit is extracted with food-grade ethanol, and the alkaloid fraction is purified by chromatographic methods and crystallized to the 98% crystalline form, or standardized to lower-assay extract powders. The raw botanical is tested for identity and contaminants before extraction, in-process checks monitor alkaloid content and solvent recovery, and finished lots are released by validated HPLC against a certified evodiamine reference standard.

Q5. What is the difference between evodiamine 98% crystalline powder and standardized Evodia extracts?

Evodiamine 98% is a purified single-molecule alkaloid, white to light-yellow in color, used when formulators need a precise milligram-level active. Standardized Evodia rutaecarpa extracts at 10%, 30% or 50% evodiamine are yellow-to-brown whole-extract powders that retain a broader botanical profile and are used for whole-herb positioning. Both are assayed by HPLC, and the choice depends on the product concept and label declaration.

Q6. Which ingredients is evodiamine commonly combined with?

Evodiamine is commonly formulated with caffeine-bearing ingredients such as green tea extract, with L-carnitine, chromium and other metabolic ingredients in thermogenic and energy products. Because evodiamine and caffeine both stimulate thermogenic pathways, combinations should be dosed conservatively and caffeine content declared accurately. Compatibility and stability testing for the specific formula are recommended before scale-up.

Q7. How does evodiamine relate to capsaicin, and what does TRPV1 activation mean?

TRPV1 is a transient receptor potential ion channel activated by heat and by pungent botanical compounds such as capsaicin. Evodiamine is described in research as a TRPV1 agonist, meaning it activates this channel, which is linked to thermogenesis and energy-expenditure signaling. This is a mechanistic explanation from preclinical studies; it does not imply that evodiamine has the same potency or effects as capsaicin in every finished product.

Q8. What is the typical use level of evodiamine in finished supplements?

Evodiamine is an active alkaloid used at low per-serving levels in thermogenic and metabolic products, commonly in the range of several milligrams to a few tens of milligrams per serving depending on the formulation concept, and lower-assay Evodia extracts are dosed correspondingly higher by weight. There is no established dietary reference value, so levels should be set conservatively by the brand and validated in stability and finished-product testing.

Q9. Is evodiamine regulated as a food ingredient, and what claim rules apply?

In the United States, evodiamine and Evodia extracts are used as dietary-supplement ingredients within the FDA structure/function framework, which prohibits disease claims. In the European Union, botanical extracts such as Evodia rutaecarpa fruit extract require novel-food authorization or an established history of food use before supplement marketing, and no EU health claim is authorized. Confirm the framework of each destination market before finalizing labels.

Q10. How is evodiamine quality verified by HPLC?

Evodiamine assay is determined by validated reverse-phase HPLC with UV detection against a certified reference standard. Related-substance testing quantifies the main related alkaloid rutaecarpine and other impurities, typically holding single impurities within specification, and loss on drying, residual solvents by GC, heavy metals, pesticide residue and microbial testing complete the lot release panel. Request the HPLC chromatogram and impurity table on the COA.

Q11. Is evodiamine suitable for vegan, allergen-free and non-GMO products?

Yes. Evodiamine is a plant-derived alkaloid extracted from Evodia rutaecarpa fruit with no animal-derived inputs, making it suitable for vegan and vegetarian formulations. The 98% crystalline product is allergen-free, gluten-free, non-GMO and non-irradiated, and residual solvent, pesticide and heavy-metal results conform to USP/EP limits. These statements are documented on request.

Q12. How should evodiamine be handled during formulation and manufacturing?

Evodiamine 98% has a bitter, pungent profile typical of alkaloids, so capsules and coated tablets are the practical finished formats, and open beverage systems should be avoided unless taste-masked. The powder should be kept sealed in a cool, dry place away from light and strong heat. Use dust control during weighing and blending, and confirm compatibility of the active with excipients and other actives in stability trials.

Q13. What quality documentation should we request when sourcing evodiamine?

Request a current specification sheet and a batch-specific Certificate of Analysis showing HPLC assay, related-alkaloid impurities, loss on drying, residual solvents, heavy metals, pesticide residue and microbial results, plus an SDS and allergen and gluten statements. Also request ISO 9001 and FSSC 22000 certificates, Kosher and Halal certificates where relevant, botanical-origin documentation and stability data for registration files.

Q14. What is the MOQ, packing and lead time for evodiamine from Purecium?

The minimum order quantity is 25 kg, and the 98% crystalline product is packed in 25 kg drums with food-grade polyethylene inner bags; standardized extracts are packed to the same drum specification. Samples and full technical documentation are available before commitment. Standard production lead time is typically 7 to 15 working days after order confirmation, with US warehouse stock enabling faster dispatch for North American customers.

Q15. Why should we source evodiamine from Purecium?

Purecium supplies evodiamine at 98% minimum HPLC purity from controlled botanical extraction, with every batch released on a full Certificate of Analysis covering assay, related alkaloids, residual solvents, heavy metals, pesticide residue and microbiology. Production follows ISO 9001 and FSSC 22000 certified systems with Kosher and Halal certification available, the minimum order is 25 kg, US warehouse inventory enables fast fulfillment, and global delivery covers Hong Kong, mainland China, the EU and beyond.

Evodiamine 98% HPLC Powder - Evodia rutaecarpa Fruit

Evodiamine 98% Powder for Thermogenic, Metabolic and Weight-Management Supplement Blends
Evodia Rutaecarpa Fruit-Derived Evodiamine at 98% HPLC from Certified Production Facilities
Embodies the essence of pure, high-quality dietary supplement ingredients
Evodiamine 98% (HPLC) Powder
Thermogenic Alkaloid Metabolism Support

Evodiamine
Purecium Evodiamine is the principal indolequinazoline alkaloid of Evodia rutaecarpa (Juss.) Benth. fruit, supplied as a B2B raw material for thermogenic, metabolic and weight-management supplements. It carries CAS 518-17-2, molecular formula C19H17N3O and molecular weight 303.36 g/mol, and is offered at 98% minimum assay by HPLC as a white to light-yellow crystalline powder, with standardized 10-50% Evodia fruit extracts also available. Produced by controlled botanical extraction and purification in China, it is vegan, allergen-free and non-irradiated, packed in 25 kg drums with a 25 kg minimum order and full COA documentation for B2B buyers.

Product name: Evodiamine (98% HPLC)
Molecular formula: C₁₉H₁₇N₃O
Starting material: Evodia rutaecarpa (Juss.) Benth. dried fruit
Grade: Phytochemical grade (98% HPLC); extract 10-50% available
Heavy Metals: Conforms to USP/EP limits
Pesticide residue: Conforms to USP/EP limits
Packing size: 25kg/drum
CAS#: 518-17-2
Molecular weight: 303.36 g/mol
Source: Botanical extraction (Evodia rutaecarpa fruit, China)
Specification: Evodiamine >=98% by HPLC; white to light-yellow crystalline powder
Country of origin: China
Residual solvent: Conforms to USP/EP limits
Allergen free/Gluten-free/Non-GMO/Vegan/Non-Irradiation:

Evodiamine Overview

Evodiamine is a bioactive indolequinazoline alkaloid isolated from the dried, nearly ripe fruit of Evodia rutaecarpa (Juss.) Benth., a plant of the Rutaceae family known in traditional Chinese medicine as Wu Zhu Yu and botanically classified as Euodiae Fructus. The compound carries CAS 518-17-2, molecular formula C19H17N3O and molecular weight 303.36 g/mol, and it is the most-studied alkaloid marker of the fruit together with the related alkaloid rutaecarpine.

For the dietary-supplement industry, evodiamine is used mainly in thermogenic and metabolic-support products, where it is valued for its capsaicin-like activation of thermogenic pathways. Purecium supplies Evodiamine as a B2B raw material for distributors, contract manufacturers, private-label producers and finished supplement brands, at 98% minimum assay by HPLC as standard.

Source & Ingredient Identity

Purecium Evodiamine is derived from Evodia rutaecarpa fruit grown in China, the traditional production region of the species. The dried, nearly ripe fruits are extracted with food-grade solvents and the extract is purified by column chromatography and crystallization to yield the white to light-yellow crystalline alkaloid at 98% minimum purity by HPLC, with the related alkaloid rutaecarpine controlled as an impurity.

The declared product is evodiamine, also written (+)-evodiamine or d-evodiamine, with CAS 518-17-2, formula C19H17N3O and molecular weight 303.36 g/mol. Buyers can specify either the purified 98% crystalline form for capsule and tablet dosing or standardized Evodia rutaecarpa fruit extracts containing 10%, 30% or 50% evodiamine by HPLC for botanical-extract positioning, and the assay method and level should always be confirmed on the specification sheet.

Key Characteristics of Evodiamine

1. Bioactive alkaloid with thermogenic signaling. Evodiamine is described in peer-reviewed research as an activator of TRPV1, the same receptor targeted by capsaicin from chili pepper, which links it to thermogenesis and energy-expenditure modulation. This mechanism is the scientific basis for its use in thermogenic and weight-management blends, although clinical evidence remains more limited than preclinical data and finished-product wording should stay within structure/function language.

2. Defined analytical identity and purity. Evodiamine is a single-molecule alkaloid with CAS 518-17-2, formula C19H17N3O and molecular weight 303.36 g/mol, melting in the range of about 265-278 degrees Celsius. Commercial quality is specified by HPLC assay, related-alkaloid impurities (principally rutaecarpine), loss on drying, residual solvents and heavy metals, giving formulators a precise, reproducible active for dose-controlled products.

3. Clean botanical profile with formulation constraints. The 98% crystalline form is white to light-yellow, non-GMO, allergen-free, gluten-free and vegan, with a characteristic bitter, pungent profile that makes encapsulation or coated-tablet formats the practical choice. Evodia extracts are yellow to brown powders with a strong herbal note, better suited to capsules and proprietary blends than to open beverage systems.

Evodiamine Manufacturing

Production begins with selection and testing of Evodia rutaecarpa fruit from contracted farms, followed by extraction of the dried fruit with food-grade ethanol, concentration, and chromatographic purification of the alkaloid fraction. The purified concentrate is crystallized, washed, dried and milled under controlled conditions, with in-process checks on alkaloid content and solvent recovery throughout the batch.

Finished lots are tested by validated HPLC against a certified evodiamine reference standard for assay and related substances, with additional testing for identification by retention and spectral match, loss on drying, residual solvents, heavy metals, pesticide residue and microbiology. Analytical methods follow the general botanical-extract approaches of the USP-NF and the Chinese Pharmacopoeia monograph for Euodiae Fructus where applicable, and results are reported on the batch Certificate of Analysis.

Applications of Evodiamine

Thermogenic and weight-management formulas are the primary application. Evodiamine is frequently combined with caffeine sources such as green tea extract, with L-carnitine and with other metabolic ingredients in energy and slimming products, where its TRPV1-mediated thermogenic signaling is the intended contribution. Because it acts through a receptor also used by capsaicin, finished formulas should be labeled and dosed conservatively, and stimulant-containing combinations require careful caffeine declaration.

Metabolic-support and energy products form the second cluster. Preclinical research on evodiamine describes effects on energy metabolism, AMPK signaling and lipid handling, and the alkaloid appears in metabolic-wellness and sports-nutrition blends alongside chromium and carnitine-type ingredients. The 30% to 50% standardized Evodia extracts are used where a whole-botanical positioning is preferred, while the 98% crystalline form is chosen for precise milligram-level actives.

Formulators should note the regulatory framework for each market: in the United States, evodiamine products follow the FDA structure/function framework without disease claims, and in the European Union botanicals such as Evodia fruit extracts require novel-food or national food authorization before food-supplement use, which must be confirmed before launch. The bitter-taste profile favors capsules and coated tablets over chewable and liquid formats.

Manufacturing & Quality Control

Purecium Evodiamine is produced in facilities operating under ISO 9001 and FSSC 22000 certified quality systems, with Kosher and Halal certification available. Every lot is tested for identity, HPLC assay of at least 98%, related-alkaloid impurities, loss on drying, residual solvents, heavy metals, pesticide residue and microbiology, and the raw botanical is screened for identity and contaminants before extraction.

Each commercial lot is traceable from fruit harvest and farm origin to finished drum, and every batch is released on a Certificate of Analysis documenting assay, impurity profile and physical data. Purecium also provides the specification sheet, SDS, allergen and gluten statements, non-GMO declarations and stability data on request, and can supply third-party laboratory reports for registration files.

Evodiamine for B2B Supplement Manufacturing

Purecium supplies Evodiamine exclusively as a B2B raw material for distributors, contract manufacturers, private-label producers and finished supplement brands. The minimum order quantity is 25 kg; the 98% crystalline product is packed in 25 kg drums with food-grade polyethylene inner bags, and samples and full documentation are available before commitment.

For North American customers, inventory is staged at Purecium's US warehouse, enabling pickup or delivery within approximately two days. Global delivery covers Hong Kong, mainland China, the EU and other regions, with export documentation prepared for every shipment, and Purecium provides specification and application guidance and technical and regulatory communication to support formulation and registration in each destination market.

Reviewed by the Chief Quality Assurance / Regulatory Affairs Specialist at Purecium for technical accuracy and regulatory alignment.
Evodiamine Frequently Asked Questions (FAQ) for B2B Buyers

Q1. What is evodiamine and where does it come from?
Evodiamine is an indolequinazoline alkaloid isolated from the dried, nearly ripe fruit of Evodia rutaecarpa (Juss.) Benth., a Rutaceae plant known in traditional Chinese medicine as Wu Zhu Yu and listed botanically as Euodiae Fructus. It carries CAS 518-17-2, molecular formula C19H17N3O and molecular weight 303.36 g/mol. Purecium supplies the purified 98% crystalline form and standardized fruit extracts containing 10% to 50% evodiamine.
Q2. What purity and specification of evodiamine does Purecium supply?
Purecium supplies evodiamine at 98% minimum assay by HPLC as a white to light-yellow crystalline powder, and standardized Evodia rutaecarpa fruit extracts at 10%, 30% and 50% evodiamine by HPLC as brown powders. Each lot is tested for assay, related alkaloids (principally rutaecarpine), loss on drying, residual solvents, heavy metals, pesticide residue and microbiology, with results on the batch Certificate of Analysis.
Q3. Why is evodiamine used in thermogenic and weight-management supplements?
Peer-reviewed research describes evodiamine as an activator of TRPV1, the same receptor that mediates capsaicin's effects from chili pepper, with associated thermogenic and energy-expenditure signaling. This mechanism supports its use in thermogenic blends, typically alongside caffeine sources such as green tea extract. Preclinical data are stronger than clinical evidence, so finished-product communication should stay within structure/function language and avoid disease claims.
Q4. How is evodiamine manufactured from the botanical source?
Dried Evodia rutaecarpa fruit is extracted with food-grade ethanol, and the alkaloid fraction is purified by chromatographic methods and crystallized to the 98% crystalline form, or standardized to lower-assay extract powders. The raw botanical is tested for identity and contaminants before extraction, in-process checks monitor alkaloid content and solvent recovery, and finished lots are released by validated HPLC against a certified evodiamine reference standard.
Q5. What is the difference between evodiamine 98% crystalline powder and standardized Evodia extracts?
Evodiamine 98% is a purified single-molecule alkaloid, white to light-yellow in color, used when formulators need a precise milligram-level active. Standardized Evodia rutaecarpa extracts at 10%, 30% or 50% evodiamine are yellow-to-brown whole-extract powders that retain a broader botanical profile and are used for whole-herb positioning. Both are assayed by HPLC, and the choice depends on the product concept and label declaration.
Q6. Which ingredients is evodiamine commonly combined with?
Evodiamine is commonly formulated with caffeine-bearing ingredients such as green tea extract, with L-carnitine, chromium and other metabolic ingredients in thermogenic and energy products. Because evodiamine and caffeine both stimulate thermogenic pathways, combinations should be dosed conservatively and caffeine content declared accurately. Compatibility and stability testing for the specific formula are recommended before scale-up.
Q7. How does evodiamine relate to capsaicin, and what does TRPV1 activation mean?
TRPV1 is a transient receptor potential ion channel activated by heat and by pungent botanical compounds such as capsaicin. Evodiamine is described in research as a TRPV1 agonist, meaning it activates this channel, which is linked to thermogenesis and energy-expenditure signaling. This is a mechanistic explanation from preclinical studies; it does not imply that evodiamine has the same potency or effects as capsaicin in every finished product.
Q8. What is the typical use level of evodiamine in finished supplements?
Evodiamine is an active alkaloid used at low per-serving levels in thermogenic and metabolic products, commonly in the range of several milligrams to a few tens of milligrams per serving depending on the formulation concept, and lower-assay Evodia extracts are dosed correspondingly higher by weight. There is no established dietary reference value, so levels should be set conservatively by the brand and validated in stability and finished-product testing.
Q9. Is evodiamine regulated as a food ingredient, and what claim rules apply?
In the United States, evodiamine and Evodia extracts are used as dietary-supplement ingredients within the FDA structure/function framework, which prohibits disease claims. In the European Union, botanical extracts such as Evodia rutaecarpa fruit extract require novel-food authorization or an established history of food use before supplement marketing, and no EU health claim is authorized. Confirm the framework of each destination market before finalizing labels.
Q10. How is evodiamine quality verified by HPLC?
Evodiamine assay is determined by validated reverse-phase HPLC with UV detection against a certified reference standard. Related-substance testing quantifies the main related alkaloid rutaecarpine and other impurities, typically holding single impurities within specification, and loss on drying, residual solvents by GC, heavy metals, pesticide residue and microbial testing complete the lot release panel. Request the HPLC chromatogram and impurity table on the COA.
Q11. Is evodiamine suitable for vegan, allergen-free and non-GMO products?
Yes. Evodiamine is a plant-derived alkaloid extracted from Evodia rutaecarpa fruit with no animal-derived inputs, making it suitable for vegan and vegetarian formulations. The 98% crystalline product is allergen-free, gluten-free, non-GMO and non-irradiated, and residual solvent, pesticide and heavy-metal results conform to USP/EP limits. These statements are documented on request.
Q12. How should evodiamine be handled during formulation and manufacturing?
Evodiamine 98% has a bitter, pungent profile typical of alkaloids, so capsules and coated tablets are the practical finished formats, and open beverage systems should be avoided unless taste-masked. The powder should be kept sealed in a cool, dry place away from light and strong heat. Use dust control during weighing and blending, and confirm compatibility of the active with excipients and other actives in stability trials.
Q13. What quality documentation should we request when sourcing evodiamine?
Request a current specification sheet and a batch-specific Certificate of Analysis showing HPLC assay, related-alkaloid impurities, loss on drying, residual solvents, heavy metals, pesticide residue and microbial results, plus an SDS and allergen and gluten statements. Also request ISO 9001 and FSSC 22000 certificates, Kosher and Halal certificates where relevant, botanical-origin documentation and stability data for registration files.
Q14. What is the MOQ, packing and lead time for evodiamine from Purecium?
The minimum order quantity is 25 kg, and the 98% crystalline product is packed in 25 kg drums with food-grade polyethylene inner bags; standardized extracts are packed to the same drum specification. Samples and full technical documentation are available before commitment. Standard production lead time is typically 7 to 15 working days after order confirmation, with US warehouse stock enabling faster dispatch for North American customers.
Q15. Why should we source evodiamine from Purecium?
Purecium supplies evodiamine at 98% minimum HPLC purity from controlled botanical extraction, with every batch released on a full Certificate of Analysis covering assay, related alkaloids, residual solvents, heavy metals, pesticide residue and microbiology. Production follows ISO 9001 and FSSC 22000 certified systems with Kosher and Halal certification available, the minimum order is 25 kg, US warehouse inventory enables fast fulfillment, and global delivery covers Hong Kong, mainland China, the EU and beyond.
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