Bulk Calcium HMB for Sports Nutrition
GMP|FSSC22000 Certificated
Embodies the essence of pure, high-quality dietary supplement ingredients
CALCIUM HMB(Ca HMB)
Muscle Support and Recovery

Premium Calcium HMB (Ca-HMB) Raw Materials by Purecium
Purecium is a leading global B2B supplier of Calcium β-Hydroxy-β-Methylbutyrate (Ca-HMB), a potent leucine metabolite critical for muscle protein synthesis and anti-catabolic support. We supply high-purity Monohydrate and Anhydrous Ca-HMB (40-mesh powder) to contract manufacturers, distributors, and terminal brands across North America and Europe. Manufactured in ISO9001 and FSSC22000 certified facilities, our Ca-HMB strictly complies with EU and USP standards for heavy metals and solvent residues. With a low MOQ of 25kg and a dedicated US warehouse offering 2-day pickup, Purecium ensures seamless supply chain integration for premium sports nutrition and healthy aging (sarcopenia) formulations.
Product name: Calcium HMB(Ca HMB)
Molecular formula: C10H18CaO6
Starting material: Sodium hypochlorite and hydrogen peroxide
Grade: Food grade
Heavy Metals: USP/EP
Pesticide residue: USP/EP
Packing size: 25kg/drum
Product available:
Calcium HMB(Calcium HMB) powder/granular Monohydrate
Calcium HMB(Calcium HMB) powder/granular Anhydrous
HMB liquid
CAS#: 135236-72-5
Molecular weight:274.32 g/mol
Source: Synthetic
Specification: 98% HPLC
Country of origin: China
Residual solvent: USP/EP
Allergen free/Gluten-free/Non-GMO/Vegan/Non-Irradiation

Clinical Mechanisms: mTOR Activation & Anti-Catabolism
HMB is a natural metabolite of the essential amino acid leucine. Ca-HMB exerts a unique dual-action mechanism critical for muscle health, particularly in untrained individuals, aging adults, and clinical recovery settings:
- Stimulates Muscle Synthesis: Ca-HMB directly activates the mTOR (mechanistic target of rapamycin) pathway, the primary cellular regulator for protein translation and muscle hypertrophy.
- Inhibits Muscle Degradation: It effectively downregulates the ubiquitin-proteasome pathway, halting the breakdown of damaged proteins. This net-positive protein balance makes it highly effective against age-related muscle loss (sarcopenia) and exercise-induced muscle damage.
- Enhanced Cell Integrity: It stabilizes muscle cell membranes and lowers inflammatory markers such as creatine kinase, significantly accelerating post-workout recovery.
Procurement & QA Fact Sheet
Designed for transparency and B2B efficiency, here are the core specifications for Purecium’s Ca-HMB:
- Physical Properties: Fine white powder, standardized to 40 mesh for optimal flowability in encapsulation and tableting.
- Heavy Metal Limits (USP/EU Compliant): Lead (Pb) < 0.5 ppm; Arsenic (As) < 3 ppm; Cadmium (Cd) < 1 ppm; Mercury (Hg) < 0.1 ppm.
- Solvent Residues: Utilizes food-grade anhydrous ethanol, strictly controlled to < 5,000 ppm per USP standards.
- Certifications: ISO9001, Kosher, Halal, FSSC22000.
- Packaging: 25kg net weight per drum (40x40x50cm, gross 28kg) in tightly sealed, moisture-proof liners.
- Logistics: 25kg MOQ. 2-day pickup from US warehouses (for US/Canada/Mexico); direct dispatch from China for the European and global markets within 1 week.
Purecium Ca-HMB Frequently Asked Questions (FAQ)
Q1: How does Ca-HMB supplementation differ from standard Leucine supplementation?
A: While HMB is a metabolite of leucine, only about 5% of dietary leucine converts into HMB endogenously (yielding just 0.2-0.4g daily). To achieve the clinically effective dose of 1-3 grams of HMB for muscle preservation and mTOR activation, direct Ca-HMB supplementation is required, bypassing the inefficient enzymatic conversion process in the liver.
Q2: Which form of Ca-HMB should I choose: Monohydrate or Anhydrous?
A: For the vast majority of dietary supplements (tablets, capsules, solid beverages), Monohydrate Ca-HMB is the preferred choice due to its superior physical stability, ease of production, and cost-effectiveness. Anhydrous Ca-HMB should only be selected for highly specialized formulations that have absolute zero-moisture tolerance, as it is highly hygroscopic and requires strict vacuum handling.
Q3: Are there any toxic solvent residues in your Ca-HMB?
A: No. Purecium strictly uses food-grade anhydrous ethanol during the production and recrystallization processes. We guarantee that residual ethanol levels are strictly controlled below 5,000 ppm, fully complying with rigorous USP safety standards.
Q4: Do you offer finished Ca-HMB products for retail?
A: Purecium is strictly a B2B raw material supplier. We do not sell finished products to individual consumers. We exclusively serve distributors, contract manufacturers, and terminal brands globally.
Q5: Can Purecium support my brand with finished OEM/White-label manufacturing?
A: Yes. While we supply the raw Ca-HMB, we partner with top-tier contract manufacturers to provide end-to-end white-label services. We can help you deliver finished Ca-HMB tablets, hard capsules, softgels, or gummies ready for the retail market.
Q6: What is your Minimum Order Quantity (MOQ) and packaging structure?
A: Our standard MOQ is 25 kg. The powder is packed in 25kg drums (Dimensions: 40cm x 40cm x 50cm; Gross weight: 28 kg) using tightly sealed, light-resistant inner bags to prevent any moisture degradation.
Q7: How fast can you deliver to North America and Europe?
A: For clients in the United States, Canada, and Mexico, we offer immediate 2-day pickup or door-to-door delivery from our US-based warehouses. For our European and other international clients, bulk orders are shipped directly from our facilities in China within one week of order confirmation.
Q8: What quality and safety certifications accompany your Ca-HMB?
A: Our manufacturing processes are highly regulated. We provide ISO9001, Kosher, Halal, and FSSC22000 certifications, ensuring our Ca-HMB meets the highest global food and pharmaceutical-grade safety standards.
Q9: Do you provide Certificates of Analysis (COA) and stability testing data?
A: Yes. Every batch is accompanied by a detailed COA confirming heavy metal and solvent limits. Furthermore, we provide data from both accelerated and long-term stability tests to QA teams and formulators upon request. Please contact [email protected].
Q10: What is the optimal storage condition and shelf life for Ca-HMB?
A: Ca-HMB has a verified shelf life of 24 months. To ensure maximum potency and prevent moisture absorption (especially for the anhydrous form), it must be stored in a tightly sealed, dry environment, away from direct light.
Q11: Is your supply chain capable of handling long-term, large-volume contracts?
A: Absolutely. Purecium maintains robust, scalable manufacturing capabilities, ensuring a consistent, long-term supply of Ca-HMB without price volatility, making us an ideal partner for large-scale contract manufacturers.
Q12: What are the primary consumer demographics I should target with Ca-HMB formulations?
A: Ca-HMB formulations are highly effective for three key demographics: aging adults experiencing muscle loss (sarcopenia), untrained individuals beginning a new resistance training regimen, and elite athletes seeking to accelerate recovery and reduce exercise-induced muscle damage.
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