Q1. What is chrysin and where does it come from?

Chrysin is a naturally occurring flavone, 5,7-dihydroxyflavone, with CAS 480-40-0, molecular formula C15H10O4 and molecular weight 254.24 g/mol. It is found in Passiflora incarnata and propolis, and commercial material is most commonly isolated from Oroxylum indicum bark, one of the richest plant sources. Purecium supplies 98% HPLC chrysin from controlled botanical extraction with per-batch source documentation.

Q2. What purity and specification of chrysin does Purecium supply?

Purecium supplies chrysin at 98% minimum assay by HPLC as a yellow to golden crystalline powder. Each lot is tested for assay, related flavonoids, identification, loss on drying, residual solvents, heavy metals, pesticide residue and microbiology, with results on the batch Certificate of Analysis.

Q3. Why is chrysin used in men's health and hormone-balance supplements?

Preclinical and in-vitro research has examined chrysin as an inhibitor of aromatase, the enzyme that converts androgens such as testosterone into estrogens, which is the basis for its use in men's health and estrogen-balance products, often alongside zinc and DIM. The evidence is largely preclinical, so finished-product communication must stay within structure/function language and avoid disease claims.

Q4. How is chrysin manufactured from the botanical source?

Chrysin-rich botanical raw material, typically Oroxylum indicum bark, is extracted with food-grade solvents and the flavone fraction is purified by chromatographic and crystallization steps, then washed, dried and milled under controlled conditions. The raw botanical is tested for identity and contaminants before extraction, in-process checks monitor flavone content and solvent recovery, and finished lots are released by validated HPLC against a certified reference standard.

Q5. Is chrysin well absorbed, and how should formulators address bioavailability?

Research reports indicate that chrysin has limited oral bioavailability in its plain crystalline form, largely due to low aqueous solubility and rapid metabolism. Formulators commonly use micronization, cyclodextrin complexation, liposomal or self-emulsifying delivery systems, and should validate the finished format with stability and dissolution testing rather than assuming absorption from standard capsules.

Q6. Which ingredients is chrysin commonly combined with?

Chrysin is commonly formulated with zinc, DIM (diindolylmethane) and other ingredients in men's health and estrogen-balance products, and with polyphenol actives such as grape-seed extract, green tea extract and resveratrol-type ingredients in antioxidant and wellness blends. Compatibility and stability testing for the specific formula are recommended before scale-up.

Q7. What does aromatase inhibition mean, and what is the research status?

Aromatase is the enzyme that converts androgens into estrogens. In-vitro studies describe chrysin as an aromatase-modulating flavonoid, which is why it appears in hormone-balance product concepts, but this evidence is preclinical and does not establish a drug-like effect in humans. Brands should communicate only structure/function effects that can be substantiated and should never imply pharmaceutical aromatase-inhibitor activity.

Q8. What is the typical use level of chrysin in finished supplements?

Chrysin is used at a wide range of per-serving levels in men's health and antioxidant blends, commonly from 50 mg up to several hundred milligrams per serving in enhanced-delivery formats, with plain crystalline chrysin at the lower end because of its solubility limitations. There is no established dietary reference value, so levels should be set by the brand and validated in stability and finished-product testing.

Q9. Is chrysin regulated as a food ingredient, and what claim rules apply?

In the United States, chrysin is used as a dietary-supplement ingredient within the FDA structure/function framework, which prohibits disease claims; in the European Union, the food-supplement status of botanical extracts containing chrysin must be confirmed against national and novel-food rules. Aromatase-related communication in particular must avoid any implication of pharmaceutical activity. Confirm the framework of each destination market before labeling.

Q10. How is chrysin quality verified by HPLC?

Chrysin assay is determined by validated reverse-phase HPLC with UV detection against a certified reference standard. Related-flavonoid testing quantifies other flavones and impurities within stated limits, and loss on drying, residual solvents by GC, heavy metals, pesticide residue and microbial testing complete the lot-release panel. Request the HPLC chromatogram and impurity table on the COA.

Q11. Is chrysin suitable for vegan, allergen-free and non-GMO products?

Yes. Chrysin is a plant-derived flavonoid extracted from botanical raw material with no animal inputs, making it suitable for vegan and vegetarian formulations. The 98% product is allergen-free, gluten-free, non-GMO and non-irradiated, and residual solvent, pesticide and heavy-metal results conform to USP/EP limits; these statements are documented on request.

Q12. How should chrysin be handled during formulation and manufacturing?

Chrysin 98% is a fine yellow powder with very low water solubility, so capsules, tablets and oil-based or solubilized formats are the practical choices, and open beverage systems are generally unsuitable unless a soluble delivery system is used. Store sealed in a cool, dry place away from strong light, use dust control during handling, and confirm compatibility with excipients and other actives in stability trials.

Q13. What quality documentation should we request when sourcing chrysin?

Request a current specification sheet and a batch-specific Certificate of Analysis showing HPLC assay, related flavonoids, loss on drying, residual solvents, heavy metals, pesticide residue and microbial results, plus an SDS and allergen and gluten statements. Also request ISO 9001 and FSSC 22000 certificates, Kosher and Halal certificates where relevant, botanical-origin documentation and stability data for registration files.

Q14. What is the MOQ, packing and lead time for chrysin from Purecium?

The minimum order quantity is 25 kg, and the 98% product is packed in 25 kg drums with food-grade polyethylene inner bags. Samples and full technical documentation are available before commitment. Standard production lead time is typically 7 to 15 working days after order confirmation, with US warehouse stock enabling faster dispatch for North American customers.

Q15. Why should we source chrysin from Purecium?

Purecium supplies chrysin at 98% minimum HPLC purity from controlled botanical extraction with documented source, and every batch is released on a full Certificate of Analysis covering assay, related flavonoids, residual solvents, heavy metals, pesticide residue and microbiology. Production follows ISO 9001 and FSSC 22000 certified systems with Kosher and Halal certification available, the minimum order is 25 kg, and US warehouse inventory enables fast fulfillment.

Chrysin 98% HPLC Flavonoid Powder for Men's Health

Chrysin 98% HPLC Bulk Powder for Men's Health and Antioxidant Supplement Blends
Oroxylum indicum-Derived 5,7-Dihydroxyflavone from Certified Botanical Production
Embodies the essence of pure, high-quality dietary supplement ingredients
Chrysin 98% HPLC Powder
Flavonoid Estrogen-Balance Support

Chrysin
Purecium Chrysin is the naturally occurring flavonoid 5,7-dihydroxyflavone, supplied as a B2B bulk raw material for men's health, hormone-balance and antioxidant supplement programs. It carries CAS 480-40-0, molecular formula C15H10O4 and molecular weight 254.24 g/mol, and is offered at 98% minimum assay by HPLC as a yellow crystalline powder of botanical origin, with Oroxylum indicum bark as the standard commercial source. Produced by controlled botanical extraction and purification in China, it is vegan, allergen-free and non-irradiated, packed in 25 kg drums with a 25 kg minimum order and complete COA documentation for B2B buyers.

Product name: Chrysin (98% HPLC)
Molecular formula: C₁₅H₁₀O₄
Starting material: Oroxylum indicum bark (botanical extraction)
Grade: Phytochemical grade (98% HPLC)
Heavy Metals: Conforms to USP/EP limits
Pesticide residue: Conforms to USP/EP limits
Packing size: 25kg/drum
CAS#: 480-40-0
Molecular weight: 254.24 g/mol
Source: Botanical extraction (Oroxylum indicum bark, China)
Specification: Chrysin >=98% by HPLC; yellow crystalline powder
Country of origin: China
Residual solvent: Conforms to USP/EP limits
Allergen free/Gluten-free/Non-GMO/Vegan/Non-Irradiation:

Chrysin Overview

Chrysin is a naturally occurring flavonoid, 5,7-dihydroxyflavone, found in Passiflora incarnata, poplar-type propolis and, at commercial scale, in the bark of Oroxylum indicum, a tree used in traditional medicine systems of South and Southeast Asia. The compound carries CAS 480-40-0, molecular formula C15H10O4 and molecular weight 254.24 g/mol, and belongs to the flavone subclass of plant polyphenols.

In dietary supplements, chrysin is used mainly in men's health and hormone-balance products, where in-vitro and preclinical research has examined its aromatase-modulating activity, and in antioxidant and anti-inflammatory blends as a general polyphenol active. Purecium supplies Chrysin as a B2B raw material at 98% minimum assay by HPLC for distributors, contract manufacturers, private-label producers and finished supplement brands.

Source & Ingredient Identity

Commercial chrysin is most commonly isolated from Oroxylum indicum bark, which is one of the richest known plant sources of the flavonoid, with Passiflora incarnata and propolis as additional natural occurrences. Purecium sources chrysin from controlled botanical raw material, which is extracted with food-grade solvents, purified and crystallized to the 98% grade, with botanical identity documented per batch.

The declared product is chrysin, also known as 5,7-dihydroxyflavone, with CAS 480-40-0, formula C15H10O4 and molecular weight 254.24 g/mol. It is a yellow to golden crystalline powder, practically insoluble in water but soluble in organic food-grade solvents used in assay work, and buyers should confirm the assay method, botanical source and particle specification on the batch documentation.

Key Characteristics of Chrysin

1. Defined flavone with a precise analytical identity. Chrysin is a single-molecule flavone, CAS 480-40-0, formula C15H10O4 and molecular weight 254.24 g/mol, assayed by validated HPLC with UV detection against a certified reference standard. Its defined structure allows reproducible dosing and clean quality control in finished products.

2. Research interest in aromatase modulation and hormone balance. Preclinical and in-vitro studies have examined chrysin as an inhibitor of aromatase, the enzyme that converts androgens to estrogens, which is the basis for its use in men's health and estrogen-balance formulas. Because the evidence is largely preclinical and oral bioavailability is reported to be limited, finished-product claims must stay within structure/function language and formulation strategies such as enhanced delivery are commonly applied.

3. Polyphenol antioxidant profile with formulation constraints. Chrysin behaves as a flavonoid antioxidant in standard assay systems and is frequently included in wellness blends for its polyphenol identity. Its low water solubility and reported bioavailability limitations make encapsulation, micronization or solubility-enhanced formats the practical choice for meaningful per-serving doses.

Chrysin Manufacturing

Production begins with selection and testing of chrysin-rich botanical raw material, typically Oroxylum indicum bark, followed by extraction with food-grade solvents, concentration, and purification of the flavone fraction by chromatographic and crystallization steps. The purified product is washed, dried and milled under controlled conditions, with in-process checks on flavone content and solvent recovery throughout the batch.

Finished lots are tested by validated HPLC against a certified chrysin reference standard for assay and related flavonoids, with additional testing for identification, loss on drying, residual solvents, heavy metals, pesticide residue and microbiology. Analytical methods follow botanical-extract approaches of the USP-NF and general AOAC procedures, and results are reported on the batch Certificate of Analysis.

Applications of Chrysin

Men's health and hormone-balance formulas are the primary application of chrysin. It is often combined with zinc, DIM (diindolylmethane), and other ingredients positioned for healthy estrogen metabolism and androgen support, where its aromatase-modulating research profile is the intended contribution. Buyers should note that regulatory agencies do not authorize disease or drug-like claims, and label communication should remain within structure/function language.

Antioxidant and wellness blends form the second cluster, pairing chrysin with other polyphenols such as grape-seed extract, green tea polyphenols and resveratrol-type ingredients in longevity, anti-aging and general antioxidant products. Because of chrysin's low aqueous solubility and limited oral bioavailability in research models, enhanced-delivery formats and sensible per-serving levels should be validated by the formulator rather than assumed.

Manufacturing & Quality Control

Purecium Chrysin is produced in facilities operating under ISO 9001 and FSSC 22000 certified quality systems, with Kosher and Halal certification available. Every lot is tested for identity, HPLC assay of at least 98%, related flavonoids, loss on drying, residual solvents, heavy metals, pesticide residue and microbiology, and the botanical raw material is screened for identity and contaminants before extraction.

Each commercial lot is traceable from plant harvest and botanical intake to finished drum, and every batch is released on a Certificate of Analysis documenting assay, impurity profile and physical data. Purecium also provides the specification sheet, SDS, allergen and gluten statements, non-GMO declarations, botanical-origin documentation and stability data on request.

Chrysin for B2B Supplement Manufacturing

Purecium supplies Chrysin exclusively as a B2B raw material for distributors, contract manufacturers, private-label producers and finished supplement brands. The minimum order quantity is 25 kg; the 98% product is packed in 25 kg drums with food-grade polyethylene inner bags, and samples with full documentation are available before commitment.

For North American customers, inventory is staged at Purecium's US warehouse, enabling pickup or delivery within approximately two days. Global delivery covers Hong Kong, mainland China, the EU and other regions, with export documentation prepared for every shipment, and Purecium provides specification and application guidance plus technical and regulatory communication to support formulation and registration in each destination market.

Reviewed by the Chief Quality Assurance / Regulatory Affairs Specialist at Purecium for technical accuracy and regulatory alignment.
Chrysin Frequently Asked Questions (FAQ) for B2B Buyers

Q1. What is chrysin and where does it come from?
Chrysin is a naturally occurring flavone, 5,7-dihydroxyflavone, with CAS 480-40-0, molecular formula C15H10O4 and molecular weight 254.24 g/mol. It is found in Passiflora incarnata and propolis, and commercial material is most commonly isolated from Oroxylum indicum bark, one of the richest plant sources. Purecium supplies 98% HPLC chrysin from controlled botanical extraction with per-batch source documentation.
Q2. What purity and specification of chrysin does Purecium supply?
Purecium supplies chrysin at 98% minimum assay by HPLC as a yellow to golden crystalline powder. Each lot is tested for assay, related flavonoids, identification, loss on drying, residual solvents, heavy metals, pesticide residue and microbiology, with results on the batch Certificate of Analysis.
Q3. Why is chrysin used in men's health and hormone-balance supplements?
Preclinical and in-vitro research has examined chrysin as an inhibitor of aromatase, the enzyme that converts androgens such as testosterone into estrogens, which is the basis for its use in men's health and estrogen-balance products, often alongside zinc and DIM. The evidence is largely preclinical, so finished-product communication must stay within structure/function language and avoid disease claims.
Q4. How is chrysin manufactured from the botanical source?
Chrysin-rich botanical raw material, typically Oroxylum indicum bark, is extracted with food-grade solvents and the flavone fraction is purified by chromatographic and crystallization steps, then washed, dried and milled under controlled conditions. The raw botanical is tested for identity and contaminants before extraction, in-process checks monitor flavone content and solvent recovery, and finished lots are released by validated HPLC against a certified reference standard.
Q5. Is chrysin well absorbed, and how should formulators address bioavailability?
Research reports indicate that chrysin has limited oral bioavailability in its plain crystalline form, largely due to low aqueous solubility and rapid metabolism. Formulators commonly use micronization, cyclodextrin complexation, liposomal or self-emulsifying delivery systems, and should validate the finished format with stability and dissolution testing rather than assuming absorption from standard capsules.
Q6. Which ingredients is chrysin commonly combined with?
Chrysin is commonly formulated with zinc, DIM (diindolylmethane) and other ingredients in men's health and estrogen-balance products, and with polyphenol actives such as grape-seed extract, green tea extract and resveratrol-type ingredients in antioxidant and wellness blends. Compatibility and stability testing for the specific formula are recommended before scale-up.
Q7. What does aromatase inhibition mean, and what is the research status?
Aromatase is the enzyme that converts androgens into estrogens. In-vitro studies describe chrysin as an aromatase-modulating flavonoid, which is why it appears in hormone-balance product concepts, but this evidence is preclinical and does not establish a drug-like effect in humans. Brands should communicate only structure/function effects that can be substantiated and should never imply pharmaceutical aromatase-inhibitor activity.
Q8. What is the typical use level of chrysin in finished supplements?
Chrysin is used at a wide range of per-serving levels in men's health and antioxidant blends, commonly from 50 mg up to several hundred milligrams per serving in enhanced-delivery formats, with plain crystalline chrysin at the lower end because of its solubility limitations. There is no established dietary reference value, so levels should be set by the brand and validated in stability and finished-product testing.
Q9. Is chrysin regulated as a food ingredient, and what claim rules apply?
In the United States, chrysin is used as a dietary-supplement ingredient within the FDA structure/function framework, which prohibits disease claims; in the European Union, the food-supplement status of botanical extracts containing chrysin must be confirmed against national and novel-food rules. Aromatase-related communication in particular must avoid any implication of pharmaceutical activity. Confirm the framework of each destination market before labeling.
Q10. How is chrysin quality verified by HPLC?
Chrysin assay is determined by validated reverse-phase HPLC with UV detection against a certified reference standard. Related-flavonoid testing quantifies other flavones and impurities within stated limits, and loss on drying, residual solvents by GC, heavy metals, pesticide residue and microbial testing complete the lot-release panel. Request the HPLC chromatogram and impurity table on the COA.
Q11. Is chrysin suitable for vegan, allergen-free and non-GMO products?
Yes. Chrysin is a plant-derived flavonoid extracted from botanical raw material with no animal inputs, making it suitable for vegan and vegetarian formulations. The 98% product is allergen-free, gluten-free, non-GMO and non-irradiated, and residual solvent, pesticide and heavy-metal results conform to USP/EP limits; these statements are documented on request.
Q12. How should chrysin be handled during formulation and manufacturing?
Chrysin 98% is a fine yellow powder with very low water solubility, so capsules, tablets and oil-based or solubilized formats are the practical choices, and open beverage systems are generally unsuitable unless a soluble delivery system is used. Store sealed in a cool, dry place away from strong light, use dust control during handling, and confirm compatibility with excipients and other actives in stability trials.
Q13. What quality documentation should we request when sourcing chrysin?
Request a current specification sheet and a batch-specific Certificate of Analysis showing HPLC assay, related flavonoids, loss on drying, residual solvents, heavy metals, pesticide residue and microbial results, plus an SDS and allergen and gluten statements. Also request ISO 9001 and FSSC 22000 certificates, Kosher and Halal certificates where relevant, botanical-origin documentation and stability data for registration files.
Q14. What is the MOQ, packing and lead time for chrysin from Purecium?
The minimum order quantity is 25 kg, and the 98% product is packed in 25 kg drums with food-grade polyethylene inner bags. Samples and full technical documentation are available before commitment. Standard production lead time is typically 7 to 15 working days after order confirmation, with US warehouse stock enabling faster dispatch for North American customers.
Q15. Why should we source chrysin from Purecium?
Purecium supplies chrysin at 98% minimum HPLC purity from controlled botanical extraction with documented source, and every batch is released on a full Certificate of Analysis covering assay, related flavonoids, residual solvents, heavy metals, pesticide residue and microbiology. Production follows ISO 9001 and FSSC 22000 certified systems with Kosher and Halal certification available, the minimum order is 25 kg, and US warehouse inventory enables fast fulfillment.
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