Vitamin E Acetate Powder for Antioxidant and Skin Health Formulas
Controlled Synthesis with Verified 50% Standardization
Embodies the essence of pure, high-quality dietary supplement ingredients
DL-Alpha-Tocopheryl 50% Vitamin E
Antioxidant Protection and Skin Health

DL-Alpha-Tocopheryl 50%
Purecium DL-Alpha-Tocopheryl Acetate 50% is a free-flowing, food-grade Vitamin E powder for antioxidant, skin health and cardiovascular formulations. Standardized to 50% vitamin E on a food-grade carrier and made from synthetic all-rac-alpha-tocopheryl acetate to USP, EP and FCC standards, our powder delivers 500 IU per gram for clean label declarations, with an HPLC assay and full Certificate of Analysis on every batch. Allergen-free, gluten-free, non-GMO and vegan, it is packed in 25 kg drums with a 25 kg minimum order, staged at our US warehouse, and supported by regulatory documentation for distributors, contract manufacturers and supplement brands worldwide.
Product name: DL-Alpha-Tocopheryl Acetate 50% (Vitamin E)
Molecular formula: C31H52O3
Starting material: Trimethylhydroquinone + Isophytol (synthetic)
Grade: USP / EP / FCC
Heavy Metals: Conforms to USP/EP
Pesticide residue: Conforms to USP/EP
Packing size: 25kg/drum
CAS#: 7695-91-2
Molecular weight: 472.74 g/mol
Source: Synthetic (all-rac), acetate ester of alpha-tocopherol
Specification: 50% vitamin E on food-grade carrier (500 IU/g)
Country of origin: China
Residual solvent: Conforms to USP/EP
Allergen free: Yes
Gluten-free: Yes
Non-GMO: Yes
Vegan: Yes (synthetic route)
Non-Irradiation: Yes

DL-Alpha-Tocopheryl Acetate Overview
DL-Alpha-Tocopheryl Acetate is the esterified, synthetic form of Vitamin E, identified by CAS number 7695-91-2, molecular formula C31H52O3 and molecular weight 472.74 g/mol. It is also known as all-rac-alpha-tocopheryl acetate, Vitamin E acetate or (+/-)-alpha-tocopherol acetate, and it is the form of vitamin E most widely used in dietary supplements because of its superior stability. The 'DL' and 'all-rac' designations indicate the synthetic racemic mixture, which is the standard reference form defined in the USP-NF and European Pharmacopoeia monographs for vitamin E.
For the dietary supplement industry, vitamin E is a core antioxidant nutrient used in immunity, skin and beauty, cardiovascular wellness and healthy-aging products, and it is a standard component of multivitamins. Purecium supplies DL-Alpha-Tocopheryl Acetate as a 50% standardized powder on a food-grade carrier, designed for tablets, capsules, sachets and powder blends, and sells exclusively as a B2B raw material for distributors, contract manufacturers, private-label producers and finished supplement brands.
Source & Ingredient Identity
Purecium DL-Alpha-Tocopheryl Acetate is manufactured by a synthetic route: condensation of trimethylhydroquinone with isophytol produces all-rac-alpha-tocopherol, which is then esterified with acetic acid to form the acetate ester. Esterification protects the phenolic hydroxyl group, making the molecule markedly more resistant to oxidation than free tocopherol and giving the acetate form its long shelf life. The finished 50% powder is produced by blending the oily acetate onto a food-grade carrier system to create a free-flowing, low-dust powder that handles cleanly in dry blending.
One specification is offered under this product line: DL-Alpha-Tocopheryl Acetate 50% powder, conforming to USP, EP and FCC monographs, produced in China and non-irradiated, with no allergens, no gluten and no GMO material. The synthetic route means the product is fully vegan, an important point for clean-label brands. For B2B buyers, the critical purchasing checks are the assay on the Certificate of Analysis, the IU equivalence used in labeling and the carrier declaration, since the carrier appears on the finished-product label.
Key Characteristics of DL-Alpha-Tocopheryl Acetate 50%
1. Standardized 50% powder with simple IU math. The product is standardized to 50% vitamin E content by HPLC, which equals 500 IU per gram using the USP equivalence of 1 mg DL-alpha-tocopheryl acetate = 1 IU. A 100 IU serving therefore requires just 200 mg of powder, keeping tablet sizes small and label declarations clean.
2. Free-flowing powder for dry formats. Unlike liquid vitamin E oils, the 50% powder blends uniformly into tablets, hard capsules, sachets, gummies and powder mixes, with defined particle size and low dust generation. It eliminates the need for oil-handling equipment and simplifies both blending and cleaning validation on dry production lines.
3. Stable, clean-label and regulation-ready. The acetate ester resists oxidation, giving a 24-month shelf life under normal storage, and the synthetic route is vegan with no animal-derived input. Vitamin E is generally recognized as safe in the United States for use in foods and is an authorized vitamin for food supplements in the European Union, supporting straightforward registration across major markets.
DL-Alpha-Tocopheryl Acetate Manufacturing Process
The synthesis begins with the condensation of trimethylhydroquinone with isophytol, which forms all-rac-alpha-tocopherol. This intermediate is then acetylated with acetic anhydride or acetic acid to yield DL-alpha-tocopheryl acetate, which is purified by distillation and standardized against the USP-NF and European Pharmacopoeia monographs. For the 50% powder grade, the acetate is blended onto a food-grade carrier under controlled conditions to achieve a uniform, free-flowing powder with a target assay of 50% vitamin E, and the blend is screened to a defined particle-size profile.
Every production stage is process-controlled, and each finished lot is verified by HPLC before release. Residual solvent, heavy metal, moisture, peroxide value and microbiological results are reported on the batch Certificate of Analysis. Because vitamin E is an antioxidant, the powder is packed with oxygen-barrier liners, and each lot is traceable from starting material to finished drum.
Applications of DL-Alpha-Tocopheryl Acetate
Antioxidant protection and skin health are the primary applications of vitamin E. Mechanistically, alpha-tocopherol is a lipid-soluble radical scavenger embedded in cell membranes, where it donates electrons to neutralize lipid peroxyl radicals and break the chain reaction of lipid oxidation. This function protects cells from oxidative stress, a role recognized by EFSA for vitamin E, and supports its classic use in immune, cardiovascular wellness and healthy-aging products, alongside ascorbic acid, which helps regenerate oxidized tocopherol.
Skin health is the second major application area: vitamin E is used in beauty-from-within supplements and topical cosmeceuticals for its antioxidant and moisturizing properties, and it is frequently co-formulated with collagen, hyaluronic acid and vitamin C in skin-support systems. Peer-reviewed research has examined vitamin E in oxidative-stress, immune and dermal contexts extensively; finished-product claims should always follow the regulations of the destination market.
DL-Alpha-Tocopheryl Acetate 50% powder is compatible with tablets, hard capsules, sachets, gummies and powder blends. It is a standard component of multivitamins and antioxidant complexes, and pairs naturally with vitamin C, zinc, selenium and omega fatty acids. The free-flowing powder format gives B2B buyers full flexibility across dry dosage forms without oil-handling complexity.
Manufacturing & Quality Control
Purecium DL-Alpha-Tocopheryl Acetate 50% is produced in facilities operating under ISO 9001 and FSSC 22000 certified quality systems, with Kosher and Halal certification available. Analytical methods follow the current USP-NF and European Pharmacopoeia monographs for Vitamin E, and each batch is assayed by HPLC for tocopherol content and by GC or HPLC for the acetate ester. Routine release testing covers identification, assay (50% min), moisture, heavy metals, residual solvents, peroxide value and microbial limits, with results documented on a batch-specific Certificate of Analysis.
Each commercial lot is fully traceable from starting material to finished drum. Alongside the CoA, Purecium provides the specification sheet, SDS, allergen and gluten statements, non-GMO declarations and stability data on request, giving buyers the documentation needed for raw-material approval and finished-product registration.
DL-Alpha-Tocopheryl Acetate for B2B Supplement Manufacturing
Purecium supplies DL-Alpha-Tocopheryl Acetate 50% exclusively as a B2B raw material for distributors, contract manufacturers, private-label producers and finished supplement brands. The minimum order quantity is 25 kg. The powder is packed in 25 kg drums with food-grade aluminum-foil inner bags, and samples and full documentation are available before commitment.
For North American customers, inventory is staged at Purecium's US warehouse, enabling pickup or delivery within approximately two days. Global delivery covers Hong Kong, mainland China, the EU and other regions, with export documentation prepared for every shipment. Purecium also supports custom blending with complementary ingredients such as vitamin C and zinc, and provides technical and regulatory communication to move vitamin E from ingredient selection to commercial formulation.
Reviewed by the Chief Quality Assurance / Regulatory Affairs Specialist at Purecium for technical accuracy and regulatory alignment.
Last updated: 2026-08-24. Purecium reviews ingredient pages periodically to keep technical data current for AI-assisted sourcing decisions.
DL-Alpha-Tocopheryl 50% Frequently Asked Questions (FAQ) for B2B Buyers
Q1. What is DL-alpha-tocopheryl acetate used for in dietary supplements?
DL-alpha-tocopheryl acetate is the synthetic, esterified form of vitamin E used in supplements primarily for antioxidant protection, skin health, immune support and cardiovascular wellness. As vitamin E, it protects cell membranes from oxidative damage, a function recognized by EFSA, and it is a standard component of multivitamins, antioxidant complexes, beauty-from-within products and healthy-aging formulas. The acetate ester is the most stable commercial form of vitamin E, which is why it dominates dry dosage formats. Purecium supplies it as a 50% standardized powder on a food-grade carrier, delivering 500 IU per gram for clean, simple label declarations in tablets, capsules, sachets and powder blends.
Q2. Why use the acetate ester instead of free tocopherol?
The acetate ester protects the phenolic hydroxyl group of alpha-tocopherol, which is the site most vulnerable to oxidation. Free tocopherols oxidize readily when exposed to air, light and heat, which shortens shelf life and complicates formulation. Acetylation makes the molecule markedly more stable, allowing a 24-month shelf life and robust handling in dry blending and tableting. The body hydrolyzes the ester in the intestine to release active alpha-tocopherol, so biological activity is equivalent on an IU basis. For B2B manufacturers, the acetate form is the practical default for tablets, capsules and multivitamin systems, while free tocopherols are reserved for niche oil-based or specialty applications.
Q3. What does the '50%' in DL-Alpha-Tocopheryl Acetate 50% mean?
The '50%' refers to the vitamin E content of the finished powder: each kilogram contains 500 grams of DL-alpha-tocopheryl acetate equivalent, with the balance being the food-grade carrier system used to convert the oily acetate into a free-flowing powder. Using the USP equivalence of 1 mg DL-alpha-tocopheryl acetate = 1 IU, the 50% grade delivers 500 IU per gram. A 100 IU serving therefore requires 200 mg of powder. The assay is verified by HPLC on every batch and reported on the CoA, and the carrier is declared on the specification sheet so buyers can plan finished-product labeling.
Q4. What is the difference between natural d-alpha-tocopherol and synthetic dl-alpha-tocopheryl acetate?
Natural vitamin E (d-alpha-tocopherol and its esters) is extracted from vegetable oils and consists of a single stereoisomer, while synthetic vitamin E (dl- or all-rac-alpha-tocopheryl acetate) is a racemic mixture of eight stereoisomers produced by chemical synthesis. The two are labeled differently: 1 mg of dl-alpha-tocopheryl acetate equals 1 IU, while 1 mg of d-alpha-tocopheryl acetate equals 1.36 IU and 1 mg of d-alpha-tocopherol equals 1.49 IU. Natural forms generally command higher prices and are used in premium, clean-label positioning, while the synthetic acetate is the cost-effective, highly stable workhorse of the supplement industry. Both are recognized by USP-NF and EP monographs. B2B buyers should match the form to their positioning and label strategy.
Q5. How do I convert the 50% powder to IU for labeling?
Use the USP equivalence: 1 mg of DL-alpha-tocopheryl acetate equals 1 IU of vitamin E. Because the 50% powder contains 500 mg of DL-alpha-tocopheryl acetate per gram, it delivers 500 IU per gram. For a 100 IU serving, add 200 mg of powder; for a 200 IU serving, add 400 mg. When the finished product uses d-alpha forms instead, the conversion factors differ (1.36 IU/mg for d-alpha-tocopheryl acetate and 1.49 IU/mg for d-alpha-tocopherol), so the label basis must match the raw material actually used. Purecium provides the assay and IU basis on the CoA, and our technical team can help verify your label math before production.
Q6. What assay and quality specifications should I expect?
A 50% DL-alpha-tocopheryl acetate powder should be assayed at 50% minimum vitamin E content by HPLC against the USP-NF or EP vitamin E monograph, with moisture typically not more than 5%, heavy metals within monograph limits, peroxide value within limits for the oil component, conforming residual solvents and microbial counts within USP/EP limits. The particle-size profile should be documented for blending performance. Purecium reports all of these on the batch Certificate of Analysis, including the assay method, the reported percentage, production date and expiry date. Buyers should always request the current CoA and confirm the assay and carrier match their internal raw-material standard.
Q7. Is this vitamin E powder suitable for direct compression tableting?
Yes. The 50% powder is specifically produced for dry blending and direct compression: the carrier system converts the oily acetate into a free-flowing, non-sticky powder that blends uniformly with excipients and other actives without oil-handling equipment or the granulation step that liquid vitamin E would require. The defined particle size supports blend uniformity and consistent tablet weight. For high-speed rotary presses, we recommend confirming the particle-size profile and lubricant system during formulation development. This powder is also suitable for hard capsules, sachets and gummies where the active can be dosed in dry form.
Q8. What quality documentation should I request when sourcing vitamin E powder?
A professional supplier should provide a current specification sheet, a batch-specific Certificate of Analysis showing identification, HPLC assay, moisture, heavy metals, residual solvents, peroxide value and microbial results, an SDS, allergen and gluten statements, and non-GMO declarations. Depending on your destination market, also request Kosher and Halal certificates, copies of the ISO 9001 and FSSC 22000 certificates, and stability data for registration purposes. Because the product is a blended powder, also confirm the carrier identity and content on the spec sheet. Purecium provides this full documentation set on request for every shipment.
Q9. Is DL-alpha-tocopheryl acetate vegan, gluten-free, allergen-free and non-GMO?
Yes. Because the synthetic route uses no animal-derived input, the product is suitable for vegan labeling, and the starting materials are non-GMO. It contains no gluten-containing ingredients and no major allergens, and the manufacturing facility follows allergen-control procedures. Allergen-free, gluten-free, non-GMO and vegan statements are provided with each shipment. Buyers should request these statements per lot because they must be documented for finished-product labeling in most regulated markets. Note that naturally sourced vitamin E from soybean oil is also non-GMO when certified, but the synthetic acetate avoids soy-allergen labeling questions entirely.
Q10. What is the MOQ and lead time for DL-alpha-tocopheryl acetate 50% from Purecium?
The minimum order quantity is 25 kg. The powder is packed in 25 kg drums with food-grade aluminum-foil inner bags, and samples and technical documentation are available before you commit. Standard production lead time is typically 7 to 15 working days after order confirmation, depending on the specification and production schedule, with faster dispatch for stocked items. For North American customers, Purecium holds inventory at its US warehouse, enabling pickup or delivery within approximately two days. Export documentation, including the Certificate of Analysis, packing list and certificate of origin, is prepared for every shipment.
Q11. Can vitamin E powder be combined with vitamin C and zinc in one formula?
Yes, this is a classic antioxidant triad. Vitamin C (ascorbic acid) is water-soluble and regenerates oxidized vitamin E, extending its antioxidant activity in the body, while zinc supports immune function and is frequently co-formulated with both vitamins in immune-support systems. All three are dry powders that blend well in tablets, capsules and sachets, though the formulator should manage moisture and avoid direct contact of ascorbic acid with reactive excipients. This combination is also common in skin-health products alongside collagen. Formulators should verify ingredient compatibility, particle-size matching and blend stability, and confirm label claims comply with destination-market regulations. Purecium can supply technical guidance for these combinations.
Q12. What grades and regulatory standards apply to vitamin E?
Purecium DL-Alpha-Tocopheryl Acetate 50% conforms to USP, EP and FCC monographs for Vitamin E, which define identity, assay, related substances, residual solvents, heavy metals and microbial limits, and it is produced under ISO 9001 and FSSC 22000 certified quality systems with Kosher and Halal certification. For regulatory positioning, vitamin E has GRAS status in the United States for use in foods and is an authorized vitamin for food supplements in the European Union, with a tolerable upper intake level established by EFSA; other markets apply their own rules, and maximum permitted dosages differ between jurisdictions. B2B buyers should verify per-market dosage limits before finalizing label strength. Purecium provides regulatory-support documents to assist with submissions.
Q13. Why is the synthetic acetate form cheaper than natural vitamin E?
Natural vitamin E is extracted from vegetable oils such as soybean and sunflower, and the purification of the single natural stereoisomer is expensive and limited by crop yields. Synthetic vitamin E is produced from petrochemical-derived trimethylhydroquinone and isophytol in a scalable condensation and acetylation process, which achieves much lower cost per IU while meeting the same USP-NF and EP monograph standards. The trade-off is positioning: natural d-alpha forms carry a premium and are preferred for premium, food-based branding, while the synthetic acetate is the standard, cost-effective choice for mainstream multivitamins and antioxidant products. B2B buyers typically carry both, selecting by product tier and price point.
Q14. How should the powder be stored, and what is the shelf life?
Store the powder in tightly sealed original containers in a cool, dry place below 25 degrees Celsius, protected from light and moisture. The acetate ester is oxidation-resistant, but the carrier can absorb moisture, so humidity control matters. Avoid heat and direct sunlight. Under these conditions, shelf life is generally 24 months from the date of manufacture. Once a container is opened, reseal it immediately after use and complete consumption within a defined period. Finished-product stability depends on the complete formulation and packaging system, so stability studies should be run on the actual product. Each shipment's CoA states the production date and expiry date for inventory planning.
Q15. Why should we source vitamin E from Purecium?
Purecium supplies DL-Alpha-Tocopheryl Acetate 50% as a B2B raw material for distributors, contract manufacturers, private-label producers and supplement brands, standardized to 50% vitamin E (500 IU/g) on a food-grade carrier and produced to USP, EP and FCC standards. Every batch is HPLC-assayed and ships with a full Certificate of Analysis, SDS and supporting documentation. The minimum order is 25 kg, inventory is staged at our US warehouse for two-day pickup, and global delivery covers Hong Kong, mainland China, the EU and beyond. For long-term supply relationships, Purecium provides consistent quality, batch traceability, regulatory documents and direct technical communication rather than one-off spot pricing.
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