Q1. What is fisetin and where does it come from?

Fisetin is a naturally occurring flavonol, 3,3',4',7-tetrahydroxyflavone, with CAS 528-48-3, molecular formula C15H10O6 and molecular weight 286.24 g/mol. It is found in plant foods including strawberry and apple and is supplied as a purified botanical extract. Purecium provides fisetin at 98% minimum assay by HPLC from natural botanical extraction.

Q2. What purity and specification of fisetin does Purecium supply?

Purecium supplies fisetin at 98% minimum assay by HPLC as a yellow powder. Each lot is tested for assay, related flavonoids, identification, loss on drying, residual solvents, heavy metals, pesticide residue and microbiology, with results on the batch Certificate of Analysis.

Q3. Why is fisetin used in antioxidant and cellular-health supplements?

Fisetin behaves as a flavonoid antioxidant and has attracted research interest for cellular-health mechanisms, including a body of preclinical research on senescence-related processes and neuroprotective activity. This profile supports its use in healthy-aging and antioxidant products; finished-product claims must stay within structure/function language and avoid disease claims.

Q4. How is fisetin manufactured?

Fisetin is produced by controlled botanical extraction: fisetin-rich plant material is extracted with food-grade solvents and the flavonol fraction is purified by chromatographic and crystallization steps to the 98% grade. The raw botanical is tested for identity and contaminants before extraction, and finished lots are released by validated HPLC against a certified fisetin reference standard.

Q5. What foods contain fisetin, and is the supplement form the same molecule?

Fisetin is reported in a range of plant foods, with strawberry and apple among the commonly cited dietary sources, and it also occurs in certain botanical materials. The purified supplement grade is the same molecule (CAS 528-48-3) at 98% minimum assay, providing a concentrated and defined form of the flavonoid that occurs only in small amounts in whole foods.

Q6. Is fisetin related to quercetin or other flavonoids?

Fisetin belongs to the flavonol subclass of flavonoids, the same family as quercetin and myricetin, and shares the general polyphenol antioxidant chemistry of the group. It differs in its specific hydroxylation pattern (3,3',4',7-tetrahydroxyflavone), which gives it a distinct analytical identity and research profile; it is sometimes called 5-deoxyquercetin because it lacks the 5-hydroxyl group of quercetin.

Q7. What is the typical use level of fisetin in finished supplements?

Fisetin is typically used at doses in the range of 100 mg up to 1000 mg per day in cellular-health products, commonly around 100-500 mg per serving in capsules. There is no established dietary reference value, so levels should be set by the brand on the basis of the product concept and confirmed in stability and finished-product testing.

Q8. Which ingredients is fisetin commonly combined with?

Fisetin is commonly formulated with resveratrol, spermidine, quercetin-type flavonoids and NAD+ precursors such as NMN in healthy-aging and cellular-health stacks. Compatibility and stability testing for the specific formula should be completed before scale-up, and per-serving levels reviewed against the regulatory framework of each destination market.

Q9. Is fisetin well absorbed, and how should formulators address bioavailability?

Like most flavonols, fisetin has limited aqueous solubility and research suggests modest oral bioavailability in its plain form. Formulators commonly use micronization, cyclodextrin complexation, liposomal or self-emulsifying delivery systems for higher-dose concepts, and should validate the finished format with stability and dissolution testing rather than assuming absorption.

Q10. How is fisetin regulated as a food ingredient?

In the United States, fisetin is used as a dietary-supplement ingredient within the FDA structure/function framework, which prohibits disease claims. In the European Union, fisetin and its botanical sources require confirmation of novel-food or established food status before food-supplement use, and assessments vary by member state. Verify the current status of each destination market before launch.

Q11. How is fisetin quality verified by HPLC?

Fisetin assay is determined by validated reverse-phase HPLC with UV detection against a certified reference standard. Related-flavonoid testing quantifies other flavonols and impurities within stated limits, and loss on drying, residual solvents by GC, heavy metals, pesticide residue and microbial testing complete the lot-release panel. Request the HPLC chromatogram and impurity table on the COA.

Q12. Is fisetin suitable for vegan and allergen-free products?

Yes. Fisetin is a plant-derived flavonoid from botanical extraction with no animal inputs, making it suitable for vegan and vegetarian formulations. It is allergen-free, gluten-free, non-GMO and non-irradiated, and residual solvent, pesticide and heavy-metal results conform to USP/EP limits; these statements are documented on request.

Q13. How should fisetin be stored and handled during formulation?

Fisetin is a fine yellow powder with low water solubility, so capsules and carrier-assisted formats are the practical choices. It should be protected from strong light, moisture and heat, stored sealed in a cool, dry place, and handled with standard dust-control measures. Confirm compatibility with excipients and other actives in stability trials before scale-up.

Q14. What documentation should we request when sourcing fisetin?

Request a current specification sheet and a batch Certificate of Analysis showing HPLC assay, related flavonoids, loss on drying, residual solvents, heavy metals, pesticide residue and microbial results, plus an SDS and allergen and gluten statements. Also request ISO 9001 and FSSC 22000 certificates, Kosher and Halal certificates where relevant, and botanical-source documentation.

Q15. What is the MOQ, packing and lead time for fisetin from Purecium?

The minimum order quantity is 25 kg, and fisetin is packed in 25 kg drums with food-grade polyethylene inner bags. Samples and full technical documentation are available before commitment. Standard production lead time is typically 10 to 20 working days after order confirmation, with US warehouse stock enabling faster dispatch for North American customers.

Fisetin 98% HPLC Bulk Powder - Strawberry & Apple Flavonoid

Fisetin 98% HPLC Bulk Powder for Antioxidant and Cellular-Health Supplement Formulas
Naturally Extracted Fisetin Flavonoid at 98% Assay from Certified Botanical Production
Embodies the essence of pure, high-quality dietary supplement ingredients
Fisetin 98% HPLC Powder
Flavonoid Antioxidant Cellular-Health Active

Fisetin
Purecium Fisetin is the naturally occurring flavonol found in strawberry and apple, supplied as a B2B bulk raw material for antioxidant, cellular-health and healthy-aging supplement programs. It carries CAS 528-48-3, molecular formula C15H10O6 and molecular weight 286.24 g/mol, and is offered at 98% minimum assay by HPLC as a yellow powder from natural botanical extraction. Produced in China under certified quality systems, it is vegan, allergen-free and non-irradiated, packed in 25 kg drums with a 25 kg minimum order and full COA documentation for B2B buyers.

Product name: Fisetin (98% HPLC)
Molecular formula: C₁₅H₁₀O₆
Starting material: Natural botanical extraction (fisetin-rich plant source)
Grade: Phytochemical grade (98% HPLC)
Heavy Metals: Conforms to USP/EP limits
Pesticide residue: Conforms to USP/EP limits
Packing size: 25kg/drum
CAS#: 528-48-3
Molecular weight: 286.24 g/mol
Source: Botanical extraction; China
Specification: Fisetin >=98% by HPLC; yellow powder
Country of origin: China
Residual solvent: Conforms to USP/EP limits
Allergen free/Gluten-free/Non-GMO/Vegan/Non-Irradiation:

Fisetin Overview

Fisetin is a naturally occurring flavonol present in a range of plant foods, with strawberry and apple among the commonly cited dietary sources, and it is also found in certain traditional botanical materials. The compound carries CAS 528-48-3, molecular formula C15H10O6 and molecular weight 286.24 g/mol, and it belongs to the flavonoid subclass that includes quercetin and myricetin.

For the dietary-supplement industry, fisetin is used in antioxidant, cellular-health and healthy-aging products, where research interest has focused on its behavior as a flavonoid antioxidant and on its senolytic and longevity-related research profile in preclinical models. Purecium supplies Fisetin as a B2B raw material at 98% minimum assay by HPLC for distributors, contract manufacturers, private-label producers and finished supplement brands.

Source & Ingredient Identity

Purecium Fisetin is obtained from natural botanical extraction: plant material rich in fisetin is extracted with food-grade solvents, and the flavonol fraction is purified by chromatographic and crystallization steps to yield the 98% grade powder. Strawberry and apple are the dietary sources commonly associated with fisetin, and the botanical identity of each commercial lot is documented on request.

The declared product is fisetin, also known as 5-deoxyquercetin or 3,3',4',7-tetrahydroxyflavone, with CAS 528-48-3, formula C15H10O6 and molecular weight 286.24 g/mol. It is a yellow to yellow-green powder with low water solubility, and buyers should confirm the assay method, botanical source and related-flavonoid profile on the specification sheet.

Key Characteristics of Fisetin

1. Defined flavonol with a distinctive research profile. Fisetin (C15H10O6, 286.24 g/mol, CAS 528-48-3) is a flavonol whose research interest extends beyond general antioxidant activity to cellular-health mechanisms, including a body of preclinical research on senescence-related processes. This positions fisetin in healthy-aging products as well as in conventional antioxidant blends.

2. Precise analytical identity for a botanical active. Commercial fisetin is specified by HPLC assay of at least 98%, related flavonoids, residual solvents, heavy metals, pesticide residue and microbiology, with identity confirmed against certified reference standards. This gives formulators a defined active for consistent dosing in premium formulas.

3. Physical profile that favors encapsulation. Fisetin is a fine yellow powder with low water solubility, making capsules and carrier-assisted formats the practical choice. It is vegan, allergen-free, gluten-free, non-GMO and non-irradiated, and should be protected from strong light, moisture and heat during storage and handling.

Fisetin Manufacturing

Fisetin is manufactured by controlled botanical extraction: fisetin-rich plant material is extracted with food-grade solvents, and the crude extract is purified by chromatographic methods and crystallization to yield the 98% minimum assay powder. The botanical raw material is tested for identity and contaminants before extraction, and in-process checks monitor flavonol content and solvent recovery throughout the batch.

Finished lots are tested by validated HPLC against a certified fisetin reference standard for assay and related flavonoids, with additional testing for identification, loss on drying, residual solvents, heavy metals, pesticide residue and microbiology. Analytical methods follow botanical-extract approaches of the USP-NF and AOAC-based procedures, and results are reported on the batch Certificate of Analysis.

Applications of Fisetin

Antioxidant and cellular-health formulas are the primary application of fisetin. It is used in healthy-aging and longevity products alongside other polyphenols and cellular-health actives such as resveratrol, spermidine and quercetin-type flavonoids, where its flavonoid antioxidant and cellular-research profile are the intended contributions; published research on fisetin spans antioxidant, neuroprotective and senescence-related areas.

Cognitive-wellness and sports-nutrition blends form the second cluster, using fisetin for general wellness and recovery positioning in capsules and powder formats. Formulators should confirm the regulatory framework per market: in the United States fisetin is used within the FDA dietary-supplement structure/function framework, while in the European Union the status of fisetin and its botanical sources must be confirmed before food-supplement use in each member state.

Manufacturing & Quality Control

Purecium Fisetin is produced in facilities operating under ISO 9001 and FSSC 22000 certified quality systems, with Kosher and Halal certification available. Every lot is tested for identity, HPLC assay of at least 98%, related flavonoids, loss on drying, residual solvents, heavy metals, pesticide residue and microbiology, and the botanical raw material is screened before extraction.

Each commercial lot is traceable from plant intake to finished drum, and every batch is released on a Certificate of Analysis documenting assay, impurity profile and physical data. Purecium also provides the specification sheet, SDS, allergen and gluten statements, non-GMO declarations, botanical-source documentation and stability data on request.

Fisetin for B2B Supplement Manufacturing

Purecium supplies Fisetin exclusively as a B2B raw material for distributors, contract manufacturers, private-label producers and finished supplement brands. The minimum order quantity is 25 kg; fisetin is packed in 25 kg drums with food-grade polyethylene inner bags, and samples with full documentation are available before commitment.

For North American customers, inventory is staged at Purecium's US warehouse, enabling pickup or delivery within approximately two days. Global delivery covers Hong Kong, mainland China, the EU and other regions, with export documentation prepared for every shipment, and Purecium provides specification and application guidance plus technical and regulatory communication to support formulation and registration in each destination market.

Reviewed by the Chief Quality Assurance / Regulatory Affairs Specialist at Purecium for technical accuracy and regulatory alignment.
Fisetin Frequently Asked Questions (FAQ) for B2B Buyers

Q1. What is fisetin and where does it come from?
Fisetin is a naturally occurring flavonol, 3,3',4',7-tetrahydroxyflavone, with CAS 528-48-3, molecular formula C15H10O6 and molecular weight 286.24 g/mol. It is found in plant foods including strawberry and apple and is supplied as a purified botanical extract. Purecium provides fisetin at 98% minimum assay by HPLC from natural botanical extraction.
Q2. What purity and specification of fisetin does Purecium supply?
Purecium supplies fisetin at 98% minimum assay by HPLC as a yellow powder. Each lot is tested for assay, related flavonoids, identification, loss on drying, residual solvents, heavy metals, pesticide residue and microbiology, with results on the batch Certificate of Analysis.
Q3. Why is fisetin used in antioxidant and cellular-health supplements?
Fisetin behaves as a flavonoid antioxidant and has attracted research interest for cellular-health mechanisms, including a body of preclinical research on senescence-related processes and neuroprotective activity. This profile supports its use in healthy-aging and antioxidant products; finished-product claims must stay within structure/function language and avoid disease claims.
Q4. How is fisetin manufactured?
Fisetin is produced by controlled botanical extraction: fisetin-rich plant material is extracted with food-grade solvents and the flavonol fraction is purified by chromatographic and crystallization steps to the 98% grade. The raw botanical is tested for identity and contaminants before extraction, and finished lots are released by validated HPLC against a certified fisetin reference standard.
Q5. What foods contain fisetin, and is the supplement form the same molecule?
Fisetin is reported in a range of plant foods, with strawberry and apple among the commonly cited dietary sources, and it also occurs in certain botanical materials. The purified supplement grade is the same molecule (CAS 528-48-3) at 98% minimum assay, providing a concentrated and defined form of the flavonoid that occurs only in small amounts in whole foods.
Q6. Is fisetin related to quercetin or other flavonoids?
Fisetin belongs to the flavonol subclass of flavonoids, the same family as quercetin and myricetin, and shares the general polyphenol antioxidant chemistry of the group. It differs in its specific hydroxylation pattern (3,3',4',7-tetrahydroxyflavone), which gives it a distinct analytical identity and research profile; it is sometimes called 5-deoxyquercetin because it lacks the 5-hydroxyl group of quercetin.
Q7. What is the typical use level of fisetin in finished supplements?
Fisetin is typically used at doses in the range of 100 mg up to 1000 mg per day in cellular-health products, commonly around 100-500 mg per serving in capsules. There is no established dietary reference value, so levels should be set by the brand on the basis of the product concept and confirmed in stability and finished-product testing.
Q8. Which ingredients is fisetin commonly combined with?
Fisetin is commonly formulated with resveratrol, spermidine, quercetin-type flavonoids and NAD+ precursors such as NMN in healthy-aging and cellular-health stacks. Compatibility and stability testing for the specific formula should be completed before scale-up, and per-serving levels reviewed against the regulatory framework of each destination market.
Q9. Is fisetin well absorbed, and how should formulators address bioavailability?
Like most flavonols, fisetin has limited aqueous solubility and research suggests modest oral bioavailability in its plain form. Formulators commonly use micronization, cyclodextrin complexation, liposomal or self-emulsifying delivery systems for higher-dose concepts, and should validate the finished format with stability and dissolution testing rather than assuming absorption.
Q10. How is fisetin regulated as a food ingredient?
In the United States, fisetin is used as a dietary-supplement ingredient within the FDA structure/function framework, which prohibits disease claims. In the European Union, fisetin and its botanical sources require confirmation of novel-food or established food status before food-supplement use, and assessments vary by member state. Verify the current status of each destination market before launch.
Q11. How is fisetin quality verified by HPLC?
Fisetin assay is determined by validated reverse-phase HPLC with UV detection against a certified reference standard. Related-flavonoid testing quantifies other flavonols and impurities within stated limits, and loss on drying, residual solvents by GC, heavy metals, pesticide residue and microbial testing complete the lot-release panel. Request the HPLC chromatogram and impurity table on the COA.
Q12. Is fisetin suitable for vegan and allergen-free products?
Yes. Fisetin is a plant-derived flavonoid from botanical extraction with no animal inputs, making it suitable for vegan and vegetarian formulations. It is allergen-free, gluten-free, non-GMO and non-irradiated, and residual solvent, pesticide and heavy-metal results conform to USP/EP limits; these statements are documented on request.
Q13. How should fisetin be stored and handled during formulation?
Fisetin is a fine yellow powder with low water solubility, so capsules and carrier-assisted formats are the practical choices. It should be protected from strong light, moisture and heat, stored sealed in a cool, dry place, and handled with standard dust-control measures. Confirm compatibility with excipients and other actives in stability trials before scale-up.
Q14. What documentation should we request when sourcing fisetin?
Request a current specification sheet and a batch Certificate of Analysis showing HPLC assay, related flavonoids, loss on drying, residual solvents, heavy metals, pesticide residue and microbial results, plus an SDS and allergen and gluten statements. Also request ISO 9001 and FSSC 22000 certificates, Kosher and Halal certificates where relevant, and botanical-source documentation.
Q15. What is the MOQ, packing and lead time for fisetin from Purecium?
The minimum order quantity is 25 kg, and fisetin is packed in 25 kg drums with food-grade polyethylene inner bags. Samples and full technical documentation are available before commitment. Standard production lead time is typically 10 to 20 working days after order confirmation, with US warehouse stock enabling faster dispatch for North American customers.
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