Q1. What is Polygonum cuspidatum extract and what is it used for in dietary supplements?

Polygonum cuspidatum extract is a standardized botanical ingredient from the root of Polygonum cuspidatum, or Japanese knotweed, used primarily for antioxidant, longevity and healthy-aging support. Its quality marker is trans-resveratrol, CAS 501-36-0, molecular formula C14H12O3, molecular weight 228.24 g/mol. Purecium supplies the extract standardized to resveratrol 50% min or 98% min by HPLC as 25 kg drum B2B raw material.

Q2. Why is Polygonum cuspidatum root a preferred source of resveratrol?

Polygonum cuspidatum root is one of the most concentrated natural sources of trans-resveratrol and its glycoside polydatin, which makes it the commercial botanical of choice for resveratrol extracts. Compared with grape-derived sources, the root allows efficient standardization to high assays such as 98% by HPLC. Buyers should confirm the plant part, species and assay method on the specification, since these directly determine marker content and pricing.

Q3. What is the difference between Resveratrol 50% and Resveratrol 98%?

Resveratrol 50% min is a broader-spectrum extract in which roughly half of the dry weight is resveratrol, with the remainder including other root polyphenols such as polydatin, emodin precursors and anthraquinone-related constituents. Resveratrol 98% min is a purified grade consisting essentially of trans-resveratrol. The 50% grade suits value-oriented antioxidant formulas; the 98% grade suits low-dosage, high-potency capsules and products where clean resveratrol content is the label claim.

Q4. How does resveratrol support antioxidant and longevity health?

Trans-resveratrol is a polyphenolic antioxidant studied for its support of cellular antioxidant defenses and for pathways associated with healthy aging, including sirtuin modulation explored in published clinical studies. Typical supplement servings range from 100 mg to 500 mg of 50% extract or 50 mg to 250 mg of 98% extract per day. Finished-product claims should follow the regulations of the destination market, including the United States and the EU.

Q5. What does the 98% HPLC specification mean in practice?

A 98% HPLC assay means each batch is standardized so that resveratrol makes up at least 98% of the extract by dry weight, quantified by high-performance liquid chromatography against a resveratrol reference standard. This gives formulators a consistent potency basis from batch to batch and supports low-milligram once-daily dosage formats. The Certificate of Analysis reports the trans-resveratrol result and, where relevant, the trans/cis ratio.

Q6. Is Polygonum cuspidatum extract safe and is it covered by regulatory reviews?

Polygonum cuspidatum extract has a long history of use in food supplements, and resveratrol-containing preparations have been assessed for food and supplement use in major markets. As with any botanical, formulators should follow market-specific guidance on dosage and claim wording for the destination country, and request stability and contaminant data for registration files.

Q7. What are the typical applications of resveratrol extract in finished products?

Polygonum cuspidatum extract is used in antioxidant protection formulas, longevity and healthy-aging products, cardiovascular wellness blends, and combination products with CoQ10, grape seed extract and other polyphenol-rich botanicals. Typical servings range from 100 mg to 500 mg of 50% extract or 50 mg to 250 mg of 98% extract per day. The extract suits capsules, tablets, stick-packs and powders.

Q8. Can Polygonum cuspidatum extract be combined with other ingredients?

Yes. Common pairings are CoQ10, grape seed extract and omega-3s for cardiovascular and antioxidant blends, and NMN, resveratrol alternatives or other polyphenols in healthy-aging formulas. The extract blends well into capsules, tablets and powders. Formulators should verify ingredient compatibility and balance the characteristic botanical note in drink formats.

Q9. Is Polygonum cuspidatum extract vegan?

Yes. Purecium's Polygonum cuspidatum extract is derived entirely from the plant root with food-grade ethanol or water extraction and no animal-derived materials, carriers or processing aids. It carries clear vegan, non-GMO, allergen-free and gluten-free statements and is suitable for vegan and vegetarian formulations.

Q10. What is polydatin, and why does it matter in the 50% grade?

Polydatin (piceid) is the glycoside form of resveratrol that occurs naturally in Polygonum cuspidatum root alongside free resveratrol. In the 50% grade the polyphenol fraction includes both forms, which is characteristic of phytoextract-type products; the 98% grade is purified to essentially free trans-resveratrol. Buyers should confirm whether the declared assay covers free resveratrol only or combined forms, as this is stated on the Certificate of Analysis.

Q11. How is botanical identity verified and adulteration prevented?

Identity is confirmed by macroscopic examination of the root source together with analytical fingerprinting against authenticated Polygonum cuspidatum reference material, per current USP-NF and European Pharmacopoeia methodology for botanical extracts. The resveratrol assay by HPLC and the polyphenol profile are additional quality signals, since the marker distribution is characteristic of the species. Each batch's CoA reports identity and assay.

Q12. What quality documentation should I request when sourcing resveratrol extract?

Request a current specification sheet, a batch-specific Certificate of Analysis showing identification, resveratrol assay by HPLC, residual solvent, heavy metals, pesticide residues and microbial results, an SDS, allergen and gluten statements, and non-GMO declarations. Also request Kosher and Halal certificates, ISO 9001 and FSSC 22000 certificates, and stability data for registration.

Q13. What is the MOQ and lead time for Polygonum cuspidatum extract from Purecium?

The minimum order quantity is 25 kg. The extract is packed in 25 kg drums with food-grade aluminum-foil inner bags, and samples and technical documentation are available before you commit. Standard production lead time is typically 7 to 15 working days after order confirmation, with faster dispatch for stocked items. For North American customers, Purecium holds inventory at its US warehouse, enabling pickup or delivery within approximately two days.

Q14. How should resveratrol extract be stored, and what is the shelf life?

Store in tightly sealed original containers in a cool, dry place below 25 degrees Celsius, protected from moisture, light and heat. The extract is stable under these conditions, and shelf life is generally 36 months from the date of manufacture. Each shipment's CoA states the production date and expiry date for inventory planning.

Q15. Why should we source Polygonum cuspidatum extract from Purecium?

Purecium supplies Polygonum cuspidatum extract standardized to resveratrol 50% min or 98% min with every batch released on a full Certificate of Analysis including identification, HPLC assay, residual solvent, heavy metal, pesticide and microbial results, an SDS and supporting documentation. Production is from verified root in ISO 9001 and FSSC 22000 certified facilities with Kosher and Halal certification available. The minimum order is 25 kg, inventory is staged at our US warehouse for fast fulfillment, and global delivery covers Hong Kong, mainland China, the EU and beyond. For long-term supply relationships, Purecium provides consistent quality, batch traceability, regulatory documents and direct technical communication.

Resveratrol 50% & 98% Polygonum Cuspidatum Root Extract

Polygonum Cuspidatum Root Extract for Longevity, Antioxidant and Healthy-Aging Formulas
50% and 98% Resveratrol Standardized Extracts from Verified Japanese Knotweed Root
Embodies the essence of pure, high-quality dietary supplement ingredients
Polygonum Cuspidatum Extract (Resveratrol 50% / 98%)
Resveratrol Standardized Longevity Botanical Extract

Polygonum Cuspidatum Extract
Purecium Polygonum Cuspidatum Extract is a standardized botanical raw material prepared from the root of Polygonum cuspidatum, commonly known as Japanese knotweed, and supplied as resveratrol 50% min or resveratrol 98% min by HPLC. The defining marker, trans-resveratrol, carries CAS 501-36-0, molecular formula C14H12O3 and molecular weight 228.24 g/mol. Produced by food-grade ethanol or water extraction from verified root, each batch is tested for identity, assay, heavy metals, pesticide residues and microbial limits. Allergen-free, gluten-free, non-GMO and vegan, it is packed in 25 kg drums with a 25 kg minimum order and full B2B documentation for distributors, manufacturers and brands worldwide.

Product name: Polygonum Cuspidatum Extract (Resveratrol 50%/98%)
Molecular formula: C₁₄H₁₂O₃ (Resveratrol)
Starting material: Polygonum cuspidatum root (ethanol/water extraction)
Grade: Food Grade
Heavy Metals: Conforms to USP/EP limits
Pesticide residue: Conforms to USP/EP limits
Packing size: 25kg/drum
CAS#: 501-36-0 (Resveratrol)
Molecular weight: 228.24 g/mol (Resveratrol)
Source: Polygonum cuspidatum root extract
Specification: Resveratrol 50% min / 98% min (HPLC)
Country of origin: China
Residual solvent: Conforms to USP/EP limits
Allergen free/Gluten-free/Non-GMO/Vegan/Non-Irradiation:

Polygonum Cuspidatum Extract Overview

Polygonum cuspidatum extract is a standardized botanical ingredient obtained from the root of Polygonum cuspidatum, the plant widely known as Japanese knotweed, and is used in dietary supplements for longevity, antioxidant and healthy-aging support. Its defining quality marker is trans-resveratrol, which carries CAS 501-36-0, molecular formula C14H12O3 and molecular weight 228.24 g/mol. Resveratrol assay by HPLC is the point by which the quality of Polygonum cuspidatum extract is standardized.

For the dietary supplement industry, Polygonum cuspidatum root is one of the most concentrated natural sources of resveratrol, and its extracts are used in antioxidant, cardiovascular wellness and healthy-aging formulas. Purecium supplies the extract standardized to resveratrol 50% min or 98% min by HPLC, sold exclusively as a B2B raw material for distributors, contract manufacturers, private-label producers and finished supplement brands.

Source & Ingredient Identity

Purecium Polygonum Cuspidatum Extract is produced from the root of Polygonum cuspidatum (synonym Fallopia japonica), sourced from verified cultivated and wild-collected material, extracted with food-grade ethanol or water under controlled temperature, concentrated and dried to a fine powder. Botanical identity is confirmed by macroscopic and organoleptic examination together with analytical fingerprinting against authenticated reference material, and the extract is standardized to the declared resveratrol assay.

The declared assays are resveratrol 50% min by HPLC and resveratrol 98% min by HPLC, with the 98% grade consisting essentially of trans-resveratrol. For B2B buyers, the critical purchasing checks are the resveratrol assay method, the trans/cis isomer ratio on the Certificate of Analysis, the extraction solvent, residual solvent, and the heavy metal and pesticide profile of the root source.

Key Characteristics of Polygonum Cuspidatum Extract

1. Standardized resveratrol potency in two commercial grades. The defining characteristics of this ingredient are its resveratrol assays of 50% min and 98% min by HPLC, allowing formulators to choose a concentrated purified grade or a broader-spectrum phytoextract grade with the accompanying root polyphenol fraction.

2. A natural source with a studied antioxidant profile. Trans-resveratrol is among the most extensively studied natural polyphenols; published research indicates support for cellular antioxidant defenses and healthy-aging pathways, and the NIH Office of Dietary Supplements discusses antioxidant nutrients and botanical polyphenols in its professional factsheets. Finished-product claims should follow the regulations of the destination market.

3. Clean, stable powder profile. The extract is a free-flowing fine powder in both grades, non-GMO, allergen-free, gluten-free and vegan, with a characteristic color ranging from light brown at 50% assay to off-white at 98% assay. It blends cleanly into antioxidant, longevity and healthy-aging supplement formulas.

Polygonum Cuspidatum Extract Manufacturing

The manufacturing process begins with selection and quality testing of Polygonum cuspidatum root, followed by extraction with food-grade ethanol or water under controlled temperature to preserve the resveratrol profile, clarification, concentration, and purification by chromatography for the 98% grade, then spray or vacuum drying to a fine powder. The extract is standardized to the declared resveratrol assay, and every stage is process-controlled with in-process checks on solvent, temperature and drying parameters.

Each finished lot is tested for resveratrol by HPLC together with identification, residual solvent, heavy metals, pesticide residues and microbial limits, all reported on the batch Certificate of Analysis. Each lot is traceable from root lot to finished drum, and analytical methods follow current USP-NF and European Pharmacopoeia approaches for botanical extracts where applicable.

Applications of Polygonum Cuspidatum Extract

Antioxidant and healthy-aging support is the primary application of Polygonum cuspidatum extract. Mechanistically, trans-resveratrol is a polyphenolic antioxidant studied for its support of cellular antioxidant defense and for sirtuin-related longevity pathways explored in published clinical studies; typical supplement servings range from 100 mg to 500 mg of 50% extract or 50 mg to 250 mg of 98% extract per day.

Cardiovascular and general wellness formulas form the second cluster. Resveratrol-rich extracts are used in heart-health blends alongside CoQ10, grape seed extract and omega-3s, and in healthy-aging products for antioxidant protection. The extract suits capsules, tablets, stick-packs and powders.

Formulators should note that Polygonum cuspidatum extract has a characteristic botanical note that is typically masked in capsules or balanced with flavors in drink mixes. The 98% grade, with its high resveratrol concentration, is suitable for once-daily low-dosage formats.

Manufacturing & Quality Control

Purecium Polygonum Cuspidatum Extract is produced in facilities operating under ISO 9001 and FSSC 22000 certified quality systems, with Kosher and Halal certification available. Analytical methods follow current USP-NF and European Pharmacopoeia approaches for botanical extracts, with resveratrol quantified by HPLC on every released batch.

Each commercial lot is fully traceable from root lot to finished drum, and the batch is released only when identity, assay, residual solvent, heavy metals, pesticide residues and microbial results are all within specification. Alongside the CoA, Purecium provides the specification sheet, SDS, allergen and gluten statements, non-GMO declarations and stability data on request.

Polygonum Cuspidatum Extract for B2B Supplement Manufacturing

Purecium supplies Polygonum Cuspidatum Extract exclusively as a B2B raw material for distributors, contract manufacturers, private-label producers and finished supplement brands. The minimum order quantity is 25 kg; the extract is packed in 25 kg drums with food-grade aluminum-foil inner bags, and samples and full documentation are available before commitment.

For North American customers, inventory is staged at Purecium's US warehouse, enabling pickup or delivery within approximately two days. Global delivery covers Hong Kong, mainland China, the EU and other regions, with export documentation prepared for every shipment. Purecium also provides grade selection guidance between the 50% and 98% assays and technical and regulatory communication to move the ingredient from selection to commercial formulation.

Reviewed by the Chief Quality Assurance / Regulatory Affairs Specialist at Purecium for technical accuracy and regulatory alignment.
Polygonum Cuspidatum Extract Frequently Asked Questions (FAQ) for B2B Buyers

Q1. What is Polygonum cuspidatum extract and what is it used for in dietary supplements?
Polygonum cuspidatum extract is a standardized botanical ingredient from the root of Polygonum cuspidatum, or Japanese knotweed, used primarily for antioxidant, longevity and healthy-aging support. Its quality marker is trans-resveratrol, CAS 501-36-0, molecular formula C14H12O3, molecular weight 228.24 g/mol. Purecium supplies the extract standardized to resveratrol 50% min or 98% min by HPLC as 25 kg drum B2B raw material.
Q2. Why is Polygonum cuspidatum root a preferred source of resveratrol?
Polygonum cuspidatum root is one of the most concentrated natural sources of trans-resveratrol and its glycoside polydatin, which makes it the commercial botanical of choice for resveratrol extracts. Compared with grape-derived sources, the root allows efficient standardization to high assays such as 98% by HPLC. Buyers should confirm the plant part, species and assay method on the specification, since these directly determine marker content and pricing.
Q3. What is the difference between Resveratrol 50% and Resveratrol 98%?
Resveratrol 50% min is a broader-spectrum extract in which roughly half of the dry weight is resveratrol, with the remainder including other root polyphenols such as polydatin, emodin precursors and anthraquinone-related constituents. Resveratrol 98% min is a purified grade consisting essentially of trans-resveratrol. The 50% grade suits value-oriented antioxidant formulas; the 98% grade suits low-dosage, high-potency capsules and products where clean resveratrol content is the label claim.
Q4. How does resveratrol support antioxidant and longevity health?
Trans-resveratrol is a polyphenolic antioxidant studied for its support of cellular antioxidant defenses and for pathways associated with healthy aging, including sirtuin modulation explored in published clinical studies. Typical supplement servings range from 100 mg to 500 mg of 50% extract or 50 mg to 250 mg of 98% extract per day. Finished-product claims should follow the regulations of the destination market, including the United States and the EU.
Q5. What does the 98% HPLC specification mean in practice?
A 98% HPLC assay means each batch is standardized so that resveratrol makes up at least 98% of the extract by dry weight, quantified by high-performance liquid chromatography against a resveratrol reference standard. This gives formulators a consistent potency basis from batch to batch and supports low-milligram once-daily dosage formats. The Certificate of Analysis reports the trans-resveratrol result and, where relevant, the trans/cis ratio.
Q6. Is Polygonum cuspidatum extract safe and is it covered by regulatory reviews?
Polygonum cuspidatum extract has a long history of use in food supplements, and resveratrol-containing preparations have been assessed for food and supplement use in major markets. As with any botanical, formulators should follow market-specific guidance on dosage and claim wording for the destination country, and request stability and contaminant data for registration files.
Q7. What are the typical applications of resveratrol extract in finished products?
Polygonum cuspidatum extract is used in antioxidant protection formulas, longevity and healthy-aging products, cardiovascular wellness blends, and combination products with CoQ10, grape seed extract and other polyphenol-rich botanicals. Typical servings range from 100 mg to 500 mg of 50% extract or 50 mg to 250 mg of 98% extract per day. The extract suits capsules, tablets, stick-packs and powders.
Q8. Can Polygonum cuspidatum extract be combined with other ingredients?
Yes. Common pairings are CoQ10, grape seed extract and omega-3s for cardiovascular and antioxidant blends, and NMN, resveratrol alternatives or other polyphenols in healthy-aging formulas. The extract blends well into capsules, tablets and powders. Formulators should verify ingredient compatibility and balance the characteristic botanical note in drink formats.
Q9. Is Polygonum cuspidatum extract vegan?
Yes. Purecium's Polygonum cuspidatum extract is derived entirely from the plant root with food-grade ethanol or water extraction and no animal-derived materials, carriers or processing aids. It carries clear vegan, non-GMO, allergen-free and gluten-free statements and is suitable for vegan and vegetarian formulations.
Q10. What is polydatin, and why does it matter in the 50% grade?
Polydatin (piceid) is the glycoside form of resveratrol that occurs naturally in Polygonum cuspidatum root alongside free resveratrol. In the 50% grade the polyphenol fraction includes both forms, which is characteristic of phytoextract-type products; the 98% grade is purified to essentially free trans-resveratrol. Buyers should confirm whether the declared assay covers free resveratrol only or combined forms, as this is stated on the Certificate of Analysis.
Q11. How is botanical identity verified and adulteration prevented?
Identity is confirmed by macroscopic examination of the root source together with analytical fingerprinting against authenticated Polygonum cuspidatum reference material, per current USP-NF and European Pharmacopoeia methodology for botanical extracts. The resveratrol assay by HPLC and the polyphenol profile are additional quality signals, since the marker distribution is characteristic of the species. Each batch's CoA reports identity and assay.
Q12. What quality documentation should I request when sourcing resveratrol extract?
Request a current specification sheet, a batch-specific Certificate of Analysis showing identification, resveratrol assay by HPLC, residual solvent, heavy metals, pesticide residues and microbial results, an SDS, allergen and gluten statements, and non-GMO declarations. Also request Kosher and Halal certificates, ISO 9001 and FSSC 22000 certificates, and stability data for registration.
Q13. What is the MOQ and lead time for Polygonum cuspidatum extract from Purecium?
The minimum order quantity is 25 kg. The extract is packed in 25 kg drums with food-grade aluminum-foil inner bags, and samples and technical documentation are available before you commit. Standard production lead time is typically 7 to 15 working days after order confirmation, with faster dispatch for stocked items. For North American customers, Purecium holds inventory at its US warehouse, enabling pickup or delivery within approximately two days.
Q14. How should resveratrol extract be stored, and what is the shelf life?
Store in tightly sealed original containers in a cool, dry place below 25 degrees Celsius, protected from moisture, light and heat. The extract is stable under these conditions, and shelf life is generally 36 months from the date of manufacture. Each shipment's CoA states the production date and expiry date for inventory planning.
Q15. Why should we source Polygonum cuspidatum extract from Purecium?
Purecium supplies Polygonum cuspidatum extract standardized to resveratrol 50% min or 98% min with every batch released on a full Certificate of Analysis including identification, HPLC assay, residual solvent, heavy metal, pesticide and microbial results, an SDS and supporting documentation. Production is from verified root in ISO 9001 and FSSC 22000 certified facilities with Kosher and Halal certification available. The minimum order is 25 kg, inventory is staged at our US warehouse for fast fulfillment, and global delivery covers Hong Kong, mainland China, the EU and beyond. For long-term supply relationships, Purecium provides consistent quality, batch traceability, regulatory documents and direct technical communication.
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Polygonum Cuspidatum Root Extract for Longevity, Antioxidant and Healthy-Aging Formulas

50% and 98% Resveratrol Standardized Extracts from Verified Japanese Knotweed Root

Embodies the essence of pure, high-quality dietary supplement ingredients

Polygonum Cuspidatum Extract (Resveratrol 50% / 98%)

Resveratrol Standardized Longevity Botanical Extract

Polygonum Cuspidatum Extract

Polygonum Cuspidatum Extract Overview

Source & Ingredient Identity

Key Characteristics of Polygonum Cuspidatum Extract

Polygonum Cuspidatum Extract Manufacturing

Applications of Polygonum Cuspidatum Extract

Manufacturing & Quality Control

Polygonum Cuspidatum Extract for B2B Supplement Manufacturing

Polygonum Cuspidatum Extract Frequently Asked Questions (FAQ) for B2B Buyers