Synephrine HCl 98% Powder for Thermogenic and Weight-Management Supplement Formulas

Synephrine HCl Overview

Synephrine HCl is the hydrochloride salt of p-synephrine, a protoalkaloid that occurs naturally in the peel of bitter orange (Citrus aurantium), a fruit used in traditional and botanical medicine systems for digestive and metabolic support. As a single-entity salt the compound carries CAS 5985-28-4, molecular formula C9H14ClNO2 and molecular weight 203.66 g/mol, while the free base p-synephrine is registered under CAS 94-07-5 with formula C9H13NO2 and molecular weight 167.20 g/mol.

For the dietary-supplement industry, synephrine is used mainly in thermogenic and weight-management products, where peer-reviewed pharmacology research describes it as an agonist at adrenergic receptors, the same receptor family that mediates the effects of endogenous catecholamines. Purecium supplies Synephrine HCl as a B2B raw material at 98% minimum assay by HPLC for distributors, contract manufacturers, private-label producers and finished supplement brands.

Source & Ingredient Identity

p-Synephrine is a naturally occurring amine of Citrus aurantium peel and is also reported in other citrus species, while commercial bulk synephrine hydrochloride is typically produced by controlled chemical synthesis to a defined salt specification. Purecium supplies the hydrochloride salt as the standard catalog item, with identity confirmed by reference-standard chromatography against the declared structure; citrus-derived and extract-based lots can be discussed for projects that require botanical provenance.

The declared product is synephrine hydrochloride, also written p-synephrine HCl or oxedrine hydrochloride, with CAS 5985-28-4, formula C9H14ClNO2 (equivalently C9H13NO2 HCl) and molecular weight 203.66 g/mol. It is a white to off-white crystalline powder with good solubility in water, assayed at 98% minimum by HPLC, and buyers should confirm the assay method, related-amine profile and salt form on the specification sheet before qualification.

Key Characteristics of Synephrine HCl

1. Defined protoalkaloid salt with an unambiguous identity. Synephrine HCl is a single-molecule salt, CAS 5985-28-4, formula C9H14ClNO2 and molecular weight 203.66 g/mol, distinct from the related amines octopamine, tyramine and phenylephrine, which are controlled as related substances. This defined identity allows precise milligram-level dosing in finished formulas and reproducible batch-to-batch analytics.

2. Adrenergic-receptor profile behind thermogenic positioning. Peer-reviewed pharmacology literature describes p-synephrine as an agonist at alpha-1 and beta adrenergic receptors, with research interest focused on energy expenditure, lipolysis and metabolic rate. Because it acts through the adrenergic system, it is commonly placed in thermogenic and weight-management products alongside caffeine sources, and finished-product claims must remain within the FDA structure/function framework.

3. Practical formulation profile. The hydrochloride salt is a white crystalline powder that dissolves readily in water, which suits capsules, tablets, stick packs and some beverage systems, though the characteristic bitter-astringent taste favors encapsulated or coated formats. It is vegan, allergen-free, gluten-free and non-GMO, and should be handled with standard dust-control measures during weighing and blending.

Synephrine HCl Manufacturing

Commercial production of synephrine hydrochloride starts from defined raw materials and follows a controlled synthetic route, or for botanical lots begins with extraction of bitter orange peel, followed by purification of the amine fraction. The hydrochloride salt is formed, crystallized, washed, dried and milled under controlled conditions, with in-process checks on assay, pH and related amines throughout the batch.

Finished lots are tested by validated HPLC against a certified synephrine reference standard for assay and related substances, including octopamine, tyramine and phenylephrine where specified. Additional tests cover identification, loss on drying, residual solvents by GC, heavy metals, pesticide residue where applicable and microbiology, with analytical procedures following the general chapters of the USP-NF and AOAC-based methods, and results reported on the batch Certificate of Analysis.

Applications of Synephrine HCl

Thermogenic and weight-management formulas are the primary application for synephrine HCl. It is frequently combined with caffeine-bearing ingredients such as green tea extract, with evodiamine and with other metabolic ingredients in energy and slimming products, where its adrenergic-receptor activity is the intended contribution. Because it is a stimulant-type alkaloid, combinations should be dosed conservatively and caffeine content declared accurately on finished labels.

Sports-nutrition energy products and metabolic-wellness blends form the second cluster, often pairing synephrine with chromium, L-carnitine and B-vitamins. Formulators should verify the regulatory framework for each market: in the United States, synephrine products follow the FDA structure/function framework for dietary supplements, while in the European Union the status of Citrus aurantium-derived alkaloids must be confirmed before food-supplement use, and several jurisdictions apply specific restrictions on stimulant-type alkaloids.

Manufacturing & Quality Control

Purecium Synephrine HCl is produced in facilities operating under ISO 9001 and FSSC 22000 certified quality systems, with Kosher and Halal certification available. Every lot is tested for identity, HPLC assay of at least 98%, related amines, loss on drying, residual solvents, heavy metals and microbiology, and the raw materials are screened for identity and purity before manufacture.

Each commercial lot is traceable from raw-material intake to finished drum, and every batch is released on a Certificate of Analysis documenting assay, impurity profile and physical data. Purecium also provides the specification sheet, SDS, allergen and gluten statements, non-GMO declarations and stability data on request, and can supply third-party laboratory reports for registration and qualification files.

Synephrine HCl for B2B Supplement Manufacturing

Purecium supplies Synephrine HCl exclusively as a B2B raw material for distributors, contract manufacturers, private-label producers and finished supplement brands. The minimum order quantity is 25 kg; the product is packed in 25 kg drums with food-grade polyethylene inner bags, and pre-shipment samples with full documentation are available before commitment.

For North American customers, inventory is staged at Purecium's US warehouse, enabling pickup or delivery within approximately two days. Global delivery covers Hong Kong, mainland China, the EU and other regions, with export documentation prepared for every shipment, and Purecium provides specification and application guidance plus technical and regulatory communication to support formulation and registration in each destination market.

Reviewed by the Chief Quality Assurance / Regulatory Affairs Specialist at Purecium for technical accuracy and regulatory alignment.