Q1. What is urolithin A and where does it come from?

Urolithin A (CAS 1143-70-0, C13H8O4, 228.20 g/mol) is a metabolite produced by gut bacteria from ellagitannins and ellagic acid, polyphenols abundant in pomegranate, walnuts and certain berries. Because not all individuals produce urolithin A from dietary ellagitannins, the purified molecule is now produced directly by controlled fermentation. Purecium supplies urolithin A at 98% minimum assay by HPLC, with urolithin B (CAS 1139-83-9, C13H8O3, 212.20 g/mol) on request.

Q2. What purity and specification of urolithin A does Purecium supply?

Purecium supplies urolithin A at 98% minimum assay by HPLC as an off-white to light-beige powder. Each lot is tested for assay, related urolithins, loss on drying, residual solvents, heavy metals and microbiology, with results on the batch Certificate of Analysis.

Q3. What is mitophagy and why is urolithin A associated with it?

Mitophagy is the cellular process that selectively recycles damaged mitochondria, maintaining the quality of the mitochondrial network that powers cellular energy production. Peer-reviewed research describes urolithin A as an inducer of mitophagy, and published clinical studies have examined its effects on mitochondrial biomarkers in humans, which is the mechanistic basis for its cellular-renewal and healthy-aging positioning.

Q4. How is urolithin A manufactured?

Urolithin A is produced by controlled fermentation in which a defined microbial strain converts a precursor substrate into urolithin A. The fermentation broth is processed by cell separation, extraction, chromatographic purification and drying to yield the 98% grade powder. Process parameters are monitored throughout, and finished lots are released by validated HPLC with related-urolithin control.

Q5. What is the difference between urolithin A and urolithin B?

Urolithin A (C13H8O4, 228.20 g/mol) and urolithin B (C13H8O3, 212.20 g/mol) are related gut-microbiota metabolites of ellagitannins that differ by one hydroxyl group. Urolithin A carries the mitophagy research profile and is the standard catalog item, while urolithin B is available on request for projects that need the full metabolite family.

Q6. Why is urolithin A supplied directly instead of as pomegranate extract?

Dietary ellagitannins from pomegranate and berries are converted to urolithin A only by specific gut bacteria, and research indicates that a large share of individuals do not produce meaningful amounts. Supplying the purified metabolite directly bypasses this variability, giving formulators a defined active with consistent dosing, which is why urolithin A is sold as a single-entity molecule.

Q7. What clinical research exists on urolithin A?

Published clinical studies have examined urolithin A supplementation in humans, reporting increases in circulating urolithin A and exploratory effects on mitochondrial and muscle-related biomarkers, building on a larger body of preclinical research on mitophagy. This evidence supports its cellular-health positioning; finished-product claims must stay within structure/function language without disease claims.

Q8. What is the typical use level of urolithin A in finished supplements?

Urolithin A is typically used at doses in the range of 250 to 1000 mg per day in clinical studies, commonly 500 mg as a daily serving in commercial products. There is no established dietary reference value, so the level should be set by the brand on the basis of the product concept and confirmed in stability and finished-product testing.

Q9. Which ingredients is urolithin A commonly combined with?

Urolithin A is commonly combined with NAD+ precursors such as NMN and NR, and with resveratrol, PQQ and CoQ10 in cellular-health and longevity stacks, pairing mitophagy support with NAD+ and mitochondrial-energy support. Compatibility and stability testing for the specific formula should be completed before scale-up.

Q10. How is urolithin A regulated as a food ingredient?

In the United States, urolithin A is used as a dietary-supplement ingredient within the FDA structure/function framework. In the European Union, urolithin A is authorized as a novel food under defined specifications and conditions of use, so EU buyers should confirm the authorized form and levels. Verify the current status of each destination market before launch.

Q11. Is urolithin A stable, and how should it be formulated?

Urolithin A is a fine powder with low water solubility, so capsules and carrier-assisted or oil-based formats are the practical choices; it should be protected from strong light, moisture and heat. Store sealed in a cool, dry place and confirm finished-product stability with accelerated and real-time studies for the specific formula.

Q12. Is urolithin A suitable for vegan and allergen-free products?

Yes. Urolithin A produced by fermentation involves no animal-derived inputs, making it suitable for vegan and vegetarian formulations. It is allergen-free, gluten-free, non-GMO and non-irradiated, and residual solvent, pesticide and heavy-metal results conform to USP/EP limits; these statements are documented on request.

Q13. How is urolithin A quality verified in the laboratory?

Urolithin A assay is determined by validated HPLC with UV detection against a certified reference standard, with related urolithins and process impurities quantified in the same system. Identification is confirmed by retention and spectral match, and loss on drying, residual solvents by GC, heavy metals and microbial testing complete the release panel. Request the HPLC chromatogram on the COA.

Q14. What documentation should we request when sourcing urolithin A?

Request a current specification sheet and a batch Certificate of Analysis showing HPLC assay, related urolithins, loss on drying, residual solvents, heavy metals and microbial results, plus an SDS and allergen and gluten statements. Also request ISO 9001 and FSSC 22000 certificates, Kosher and Halal certificates where relevant, fermentation-source documentation and stability data for registration files.

Q15. What is the MOQ, packing and lead time for urolithin A from Purecium?

The minimum order quantity is 25 kg, and urolithin A is packed in 25 kg drums with food-grade polyethylene inner bags. Samples and full technical documentation are available before commitment. Standard production lead time is typically 15 to 25 working days after order confirmation, with US warehouse stock enabling faster dispatch for North American customers.

Urolithin A 98% Bulk Powder - Fermentation-Derived Metabolite

Urolithin A 98% Bulk Powder for Mitophagy and Cellular-Renewal Supplement Programs
Fermentation-Produced Urolithin A from Certified Facilities, with Urolithin B Available on Request
Embodies the essence of pure, high-quality dietary supplement ingredients
Urolithin A Powder (98% HPLC)
Mitophagy Support Cellular-Renewal Active

Urolithin A
Purecium Urolithin A is the gut-microbiota metabolite of ellagitannins from pomegranate and berries, now produced by controlled fermentation and supplied as a B2B bulk active for cellular-renewal, muscle-health and healthy-aging supplement programs. It carries CAS 1143-70-0, molecular formula C13H8O4 and molecular weight 228.20 g/mol, and is offered at 98% minimum assay by HPLC as an off-white to light-beige powder. Vegan, allergen-free and non-irradiated, it is packed in 25 kg drums with a 25 kg minimum order; Urolithin B (C13H8O3, 212.20 g/mol) is available on request.

Product name: Urolithin A (98% HPLC)
Molecular formula: C₁₃H₈O₄
Starting material: Fermentation (microbial conversion of precursor substrate)
Grade: Supplement grade (>=98% HPLC)
Heavy Metals: Conforms to USP/EP limits
Pesticide residue: Conforms to USP/EP limits
Packing size: 25kg/drum
CAS#: 1143-70-0
Molecular weight: 228.20 g/mol
Source: Controlled fermentation; China
Specification: Urolithin A >=98% by HPLC; off-white to light-beige powder
Country of origin: China
Residual solvent: Conforms to USP/EP limits
Allergen free/Gluten-free/Non-GMO/Vegan/Non-Irradiation:

Urolithin A Overview

Urolithin A is a metabolite produced by gut bacteria from ellagitannins and ellagic acid, polyphenols that are abundant in pomegranate, walnuts and certain berries. The compound carries CAS 1143-70-0, molecular formula C13H8O4 and molecular weight 228.20 g/mol, and it belongs to the dibenzopyranone (urolithin) family of microbial metabolites.

For the dietary-supplement industry, urolithin A is used in cellular-renewal, muscle-health and healthy-aging products, where its most studied mechanism is the activation of mitophagy, the selective recycling of damaged mitochondria. Because direct dietary intake of ellagitannins does not reliably produce urolithin A in all individuals, the purified molecule is supplied directly as an active. Purecium supplies Urolithin A as a B2B raw material at 98% minimum assay by HPLC, with Urolithin B (CAS 1139-83-9, C13H8O3, 212.20 g/mol) available on request.

Source & Ingredient Identity

Purecium Urolithin A is produced by controlled fermentation rather than by chemical synthesis or extraction from fruit, a route that provides a consistent, scalable and cost-effective supply of the pure metabolite. The fermentation is followed by downstream purification, isolation and drying to yield the 98% minimum assay powder, with the process documented from inoculum to finished lot.

The declared product is urolithin A, also written 3,8-dihydroxy-6H-dibenzo[b,d]pyran-6-one or 3,8-dihydroxyurolithin, with CAS 1143-70-0, formula C13H8O4 and molecular weight 228.20 g/mol. Urolithin B (3-hydroxy-6H-dibenzo[b,d]pyran-6-one, CAS 1139-83-9, C13H8O3, 212.20 g/mol) is available on request, and buyers should confirm the assay method and related-urolithin profile on the specification sheet.

Key Characteristics of Urolithin A

1. Defined microbial metabolite with a studied mechanism. Urolithin A is the gut-microbiota metabolite of ellagitannins whose research profile centers on mitophagy activation, the cellular process that recycles damaged mitochondria to maintain energy production and cellular health. This mechanism-based positioning distinguishes urolithin A from general polyphenol ingredients.

2. Precise analytical identity for a high-value active. Urolithin A is specified by HPLC assay of at least 98%, related urolithins and process impurities, residual solvents, heavy metals and microbiology. Identity is confirmed by chromatographic and spectral methods against certified reference standards, giving formulators a reproducible active for milligram-level dosing.

3. Physical profile suited to encapsulation. Urolithin A is an off-white to light-beige fine powder with low water solubility, which makes capsules and oil-based or carrier-assisted formats the practical choice. It is vegan, allergen-free, gluten-free, non-GMO and non-irradiated, and should be handled with standard dust control and moisture protection.

Urolithin A Manufacturing

Urolithin A is manufactured by controlled fermentation in which a defined microbial strain converts the precursor substrate into urolithin A, followed by cell separation, extraction, chromatographic purification and crystallization or drying. Process parameters such as pH, temperature, oxygen and fermentation time are monitored to maximize yield and purity, and the purified product is milled to specification.

Finished lots are tested by validated HPLC for assay and related substances, with identification confirmed by retention time and spectral match. Additional testing covers loss on drying, residual solvents, heavy metals and microbiology, following current pharmacopeial general chapters and AOAC-based procedures, and results are reported on the batch Certificate of Analysis.

Applications of Urolithin A

Cellular-renewal and healthy-aging formulas are the primary application of urolithin A. It is used in longevity and cellular-health products alongside other NAD+-supporting and mitochondrial actives, where its mitophagy mechanism is the intended contribution, and published clinical studies have examined urolithin A's effects on mitochondrial biomarkers and muscle-related outcomes in older adults.

Muscle-health and active-lifestyle products form the second cluster, using urolithin A for muscle function and recovery positioning, typically in capsules with other cellular-health actives. Formulators should confirm the regulatory framework per market: in the United States urolithin A is used within the FDA dietary-supplement framework, while in the European Union urolithin A is authorized as a novel food under defined specifications, so the current status of each destination market should be verified before launch.

Manufacturing & Quality Control

Purecium Urolithin A is produced in facilities operating under ISO 9001 and FSSC 22000 certified quality systems, with Kosher and Halal certification available. Every lot is tested for identity, HPLC assay of at least 98%, related urolithins, loss on drying, residual solvents, heavy metals and microbiology.

Each commercial lot is traceable from inoculum and substrate intake through fermentation and purification to the finished drum, and every batch is released on a Certificate of Analysis documenting assay, impurity profile and physical data. Purecium also provides the specification sheet, SDS, allergen and gluten statements, non-GMO declarations and stability data on request.

Urolithin A for B2B Supplement Manufacturing

Purecium supplies Urolithin A exclusively as a B2B raw material for distributors, contract manufacturers, private-label producers and finished supplement brands. The minimum order quantity is 25 kg; urolithin A is packed in 25 kg drums with food-grade polyethylene inner bags, and samples with full documentation are available before commitment.

For North American customers, inventory is staged at Purecium's US warehouse, enabling pickup or delivery within approximately two days. Global delivery covers Hong Kong, mainland China, the EU and other regions, with export documentation prepared for every shipment, and Purecium provides specification and application guidance plus technical and regulatory communication to support formulation and registration in each destination market.

Reviewed by the Chief Quality Assurance / Regulatory Affairs Specialist at Purecium for technical accuracy and regulatory alignment.
Urolithin A Frequently Asked Questions (FAQ) for B2B Buyers

Q1. What is urolithin A and where does it come from?
Urolithin A (CAS 1143-70-0, C13H8O4, 228.20 g/mol) is a metabolite produced by gut bacteria from ellagitannins and ellagic acid, polyphenols abundant in pomegranate, walnuts and certain berries. Because not all individuals produce urolithin A from dietary ellagitannins, the purified molecule is now produced directly by controlled fermentation. Purecium supplies urolithin A at 98% minimum assay by HPLC, with urolithin B (CAS 1139-83-9, C13H8O3, 212.20 g/mol) on request.
Q2. What purity and specification of urolithin A does Purecium supply?
Purecium supplies urolithin A at 98% minimum assay by HPLC as an off-white to light-beige powder. Each lot is tested for assay, related urolithins, loss on drying, residual solvents, heavy metals and microbiology, with results on the batch Certificate of Analysis.
Q3. What is mitophagy and why is urolithin A associated with it?
Mitophagy is the cellular process that selectively recycles damaged mitochondria, maintaining the quality of the mitochondrial network that powers cellular energy production. Peer-reviewed research describes urolithin A as an inducer of mitophagy, and published clinical studies have examined its effects on mitochondrial biomarkers in humans, which is the mechanistic basis for its cellular-renewal and healthy-aging positioning.
Q4. How is urolithin A manufactured?
Urolithin A is produced by controlled fermentation in which a defined microbial strain converts a precursor substrate into urolithin A. The fermentation broth is processed by cell separation, extraction, chromatographic purification and drying to yield the 98% grade powder. Process parameters are monitored throughout, and finished lots are released by validated HPLC with related-urolithin control.
Q5. What is the difference between urolithin A and urolithin B?
Urolithin A (C13H8O4, 228.20 g/mol) and urolithin B (C13H8O3, 212.20 g/mol) are related gut-microbiota metabolites of ellagitannins that differ by one hydroxyl group. Urolithin A carries the mitophagy research profile and is the standard catalog item, while urolithin B is available on request for projects that need the full metabolite family.
Q6. Why is urolithin A supplied directly instead of as pomegranate extract?
Dietary ellagitannins from pomegranate and berries are converted to urolithin A only by specific gut bacteria, and research indicates that a large share of individuals do not produce meaningful amounts. Supplying the purified metabolite directly bypasses this variability, giving formulators a defined active with consistent dosing, which is why urolithin A is sold as a single-entity molecule.
Q7. What clinical research exists on urolithin A?
Published clinical studies have examined urolithin A supplementation in humans, reporting increases in circulating urolithin A and exploratory effects on mitochondrial and muscle-related biomarkers, building on a larger body of preclinical research on mitophagy. This evidence supports its cellular-health positioning; finished-product claims must stay within structure/function language without disease claims.
Q8. What is the typical use level of urolithin A in finished supplements?
Urolithin A is typically used at doses in the range of 250 to 1000 mg per day in clinical studies, commonly 500 mg as a daily serving in commercial products. There is no established dietary reference value, so the level should be set by the brand on the basis of the product concept and confirmed in stability and finished-product testing.
Q9. Which ingredients is urolithin A commonly combined with?
Urolithin A is commonly combined with NAD+ precursors such as NMN and NR, and with resveratrol, PQQ and CoQ10 in cellular-health and longevity stacks, pairing mitophagy support with NAD+ and mitochondrial-energy support. Compatibility and stability testing for the specific formula should be completed before scale-up.
Q10. How is urolithin A regulated as a food ingredient?
In the United States, urolithin A is used as a dietary-supplement ingredient within the FDA structure/function framework. In the European Union, urolithin A is authorized as a novel food under defined specifications and conditions of use, so EU buyers should confirm the authorized form and levels. Verify the current status of each destination market before launch.
Q11. Is urolithin A stable, and how should it be formulated?
Urolithin A is a fine powder with low water solubility, so capsules and carrier-assisted or oil-based formats are the practical choices; it should be protected from strong light, moisture and heat. Store sealed in a cool, dry place and confirm finished-product stability with accelerated and real-time studies for the specific formula.
Q12. Is urolithin A suitable for vegan and allergen-free products?
Yes. Urolithin A produced by fermentation involves no animal-derived inputs, making it suitable for vegan and vegetarian formulations. It is allergen-free, gluten-free, non-GMO and non-irradiated, and residual solvent, pesticide and heavy-metal results conform to USP/EP limits; these statements are documented on request.
Q13. How is urolithin A quality verified in the laboratory?
Urolithin A assay is determined by validated HPLC with UV detection against a certified reference standard, with related urolithins and process impurities quantified in the same system. Identification is confirmed by retention and spectral match, and loss on drying, residual solvents by GC, heavy metals and microbial testing complete the release panel. Request the HPLC chromatogram on the COA.
Q14. What documentation should we request when sourcing urolithin A?
Request a current specification sheet and a batch Certificate of Analysis showing HPLC assay, related urolithins, loss on drying, residual solvents, heavy metals and microbial results, plus an SDS and allergen and gluten statements. Also request ISO 9001 and FSSC 22000 certificates, Kosher and Halal certificates where relevant, fermentation-source documentation and stability data for registration files.
Q15. What is the MOQ, packing and lead time for urolithin A from Purecium?
The minimum order quantity is 25 kg, and urolithin A is packed in 25 kg drums with food-grade polyethylene inner bags. Samples and full technical documentation are available before commitment. Standard production lead time is typically 15 to 25 working days after order confirmation, with US warehouse stock enabling faster dispatch for North American customers.
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