5-HTP(5-Hydroxytryptophan)
Calm Mood, Restful Sleep
5-HTP(5-Hydroxytryptophan)
5-HTP, a natural amino acid, boosts serotonin production—key for mood regulation and sleep. Derived from Griffonia simplicifolia seeds, it eases stress, promotes emotional balance, and supports healthier sleep cycles. Ideal for those facing occasional low mood or sleep disruptions, it’s a popular choice in natural wellness supplements, offering gentle, effective support for mental and restful well-being.
Product name: 5-HTP(5-Hydroxytryptophan)
Molecular formula: C₁₁H₁₂N₂O₃
Starting material: Corn/Griffonia simplicifolia
Grade: Food grade
Heavy Metals: USP/EP
Pesticide residue: USP/EP
Packing size: 25kg/drum
CAS#: 56-69-9
Molecular weight:220.22 g/mol
Source: Fermentation/Natural
Specification: 98% HPLC
Country of origin: China
Residual solvent: USP/EP
Allergen free/Gluten-free/Non-GMO/Vegan/Non-Irridiation
5-HTP, a compound well - known for its role in mood regulation and sleep improvement, is derived from two main sources in the current market. The traditional source is the seeds of Griffonia simplicifolia, a plant native to Africa, often referred to as Ghana seeds. These seeds have been the primary raw material for 5 - HTP extraction for a long time. In African folk medicine, the plant has been used for various purposes, and its seeds, rich in 5 - HTP, are a natural reservoir of this beneficial compound. Extracting 5 - HTP from Ghana seeds involves a series of processes such as grinding the seeds, using solvents to separate the 5 - HTP from other components, and then purifying it to obtain the final product.
Economically, the market price of corn - fermented 5 - HTP is approximately half that of the natural extraction source. The cost - effectiveness of the fermentation method is attributed to several factors. Firstly, corn is a widely available and relatively inexpensive raw material compared to the limited and seasonally - available Ghana seeds. Secondly, the fermentation process can be scaled up more easily, allowing for mass production, which further reduces the per - unit cost. As a result, more consumers can access 5 - HTP supplements at a more affordable price, driving the growth of the fermentation - sourced 5 - HTP segment in the market.
In 5-HTP quality control, Peak X—a critical impurity marker—demands strict monitoring due to potential safety implications. Found in trace amounts when not properly controlled, this compound is often linked to raw material variability or incomplete purification, making it a key focus for manufacturers and regulators. Importantly, both naturally extracted and fermentation-sourced 5-HTP can achieve Peak X-free status with advanced purification techniques.
Natural 5-HTP from Griffonia simplicifolia seeds historically faced higher Peak X risks due to isolating 5-HTP from complex plant matrices, which may contain co-occurring compounds that co-elute with Peak X during purification. Seasonal variations in seed composition, soil conditions, or harvesting methods can complicate impurity control, but modern refining processes—such as enhanced chromatography and selective solvent extraction—now enable Peak X-free natural extracts, though they require more intensive processing.
Fermentation-sourced 5-HTP, by contrast, inherently simplifies Peak X management, making Peak X-free production more straightforward. Using corn-derived substrates and controlled microbial processes, fermentation minimizes co-extracted plant-based impurities from the start. Microorganisms convert simple sugars into 5-HTP in a sterile, standardized environment, limiting the formation of Peak X-related byproducts. Tighter process control—including pH, temperature, and nutrient regulation—paired with targeted purification, ensures consistent Peak X-free purity, with far lower initial impurity levels than natural extracts before refinement. This efficiency not only enhances product safety but also streamlines quality checks, making fermentation-sourced 5-HTP a preferred choice for brands prioritizing stringent impurity management.
5-HTP, a precursor to serotonin, plays key roles in mood and sleep regulation. By boosting serotonin levels in the brain, it helps alleviate occasional low mood, reduces feelings of stress, and promotes emotional balance.
It also supports healthier sleep cycles by aiding melatonin production, easing difficulties in falling or staying asleep. Additionally, 5-HTP may help manage appetite by influencing satiety signals, supporting weight management efforts.
Widely used in supplements, its natural mechanism makes it a popular choice for those seeking gentle support for mental well-being, restful sleep, and overall emotional equilibrium.
