Q1. What is NR HCL and how does it relate to vitamin B3?

NR HCL is nicotinamide riboside chloride (CAS 23111-00-4, C11H15ClN2O5, 290.70 g/mol), the chloride salt of nicotinamide riboside, a naturally occurring form of vitamin B3. NR is a precursor of NAD+ and is distinguished from niacin and nicotinamide by its riboside structure; the free cation is registered as CAS 1341-23-7. Purecium supplies NR HCL at 98% minimum assay by HPLC.

Q2. What purity and specification of NR HCL does Purecium supply?

Purecium supplies NR HCL at 98% minimum assay by HPLC as a white to off-white free-flowing crystalline powder. Each lot is tested for assay, residual nicotinamide, related impurities, chloride content, loss on drying, residual solvents, heavy metals and microbiology, with full results on the batch Certificate of Analysis.

Q3. How is NR HCL manufactured?

NR HCL is produced by a controlled synthetic route from D-ribose and nicotinamide: the ribose is activated and coupled to nicotinamide to form the riboside, which is converted to the hydrochloride salt and purified by chromatographic and crystallization steps. In-process checks monitor completion, impurities and salt stoichiometry, and finished lots are released by validated HPLC.

Q4. What is the difference between NR and NMN?

NR (nicotinamide riboside) and NMN (nicotinamide mononucleotide) are both NAD+ precursors but are chemically distinct: NR is the unphosphorylated riboside (supplied as the chloride salt, C11H15ClN2O5), while NMN is the phosphorylated mononucleotide (C11H15N2O8P). In the NAD+ salvage pathway NMN sits one step closer to NAD+; both are researched for supporting cellular NAD+ pools, and NR has a comparatively large body of published human clinical data.

Q5. What clinical research exists on NR and NAD+?

A substantial body of published clinical studies has examined NR supplementation in humans, reporting consistent and dose-dependent increases in blood NAD+ levels with good tolerability, along with exploratory research on metabolic and cellular-health markers. This human evidence base is one of the main reasons NR is positioned as a premium NAD+ precursor; finished-product claims must still stay within structure/function language.

Q6. What is the typical use level of NR HCL in finished supplements?

NR is typically used at doses of 100 to 300 mg per serving or per day in NAD+-support products, which is the range most frequently studied in published clinical trials. There is no established dietary reference value for NAD+ precursors, so the level should be set by the brand on the basis of the product concept and confirmed in stability and finished-product testing.

Q7. Which ingredients is NR commonly combined with?

NR is commonly formulated with NMN, resveratrol, PQQ and CoQ10 in cellular-energy and longevity stacks, and with B-complex vitamins in energy products. Because NR is a B3 vitamer, formulators should account for total B3 contribution in the formula and keep combined levels within applicable guidance, validating stability and compatibility in the finished format.

Q8. Is NR stable, and how should it be formulated?

NR HCL is a free-flowing crystalline powder with good water solubility and defined stability in dry formats. Capsules, tablets and stick-packs are the practical choices, and the powder should be stored sealed in a cool, dry place away from direct light and moisture. Finished-product stability should be confirmed with accelerated and real-time studies for the specific formula.

Q9. How is NR HCL regulated as a food ingredient?

In the United States, NR is used as a dietary-supplement ingredient within the FDA framework as a B3 vitamer, with structure/function communication only. In the European Union, nicotinamide riboside chloride has received novel-food authorization under defined specifications and conditions of use, so EU buyers should confirm the authorized form and levels. Verify the current status of each destination market before launch.

Q10. Is NR HCL suitable for vegan and allergen-free products?

Yes. NR HCL is produced by synthesis from D-ribose and nicotinamide with no animal-derived inputs, making it suitable for vegan and vegetarian formulations. It is allergen-free, gluten-free and non-GMO, and lots are non-irradiated with residual solvent and heavy-metal results conforming to USP/EP limits; these statements are documented on request.

Q11. How is NR HCL quality verified in the laboratory?

NR HCL assay is determined by validated HPLC against a certified reference standard, with residual nicotinamide and related impurities quantified in the same system. Identification is confirmed by retention and spectral match, chloride content by titration, and loss on drying, residual solvents by GC, heavy metals and microbial testing complete the release panel. Request the HPLC chromatogram on the COA.

Q12. What is the difference between the chloride salt and other salt forms of NR?

NR is a cationic molecule that is commercially supplied as a salt; the chloride salt (NR HCL) is the most widely used form in supplements and the form covered by the EU novel-food authorization. Other salt forms such as the tartrate have been used in some products, but chloride is the standard commercial grade supplied by Purecium at 98% minimum assay.

Q13. What documentation should we request when sourcing NR HCL?

Request a current specification sheet and a batch Certificate of Analysis showing HPLC assay, residual nicotinamide, related impurities, chloride content, loss on drying, residual solvents, heavy metals and microbial results, plus an SDS and allergen and gluten statements. Also request ISO 9001 and FSSC 22000 certificates, Kosher and Halal certificates where relevant, and stability data for registration files.

Q14. What is the MOQ, packing and lead time for NR HCL from Purecium?

The minimum order quantity is 25 kg, and NR HCL is packed in 25 kg drums with food-grade polyethylene inner bags. Samples and full technical documentation are available before commitment. Standard production lead time is typically 10 to 20 working days after order confirmation, with US warehouse stock enabling faster dispatch for North American customers.

Q15. Why should we source NR HCL from Purecium?

Purecium supplies NR HCL at 98% minimum HPLC purity from controlled synthesis, and every batch is released on a full Certificate of Analysis covering assay, residual nicotinamide, related impurities, residual solvents, heavy metals and microbiology. Production follows ISO 9001 and FSSC 22000 certified systems with Kosher and Halal certification available, the minimum order is 25 kg, and US warehouse inventory enables fast fulfillment.

NR HCL 98% Bulk Powder - Nicotinamide Riboside Chloride

NR HCL (Nicotinamide Riboside Chloride) Bulk Powder for NAD+ and Cellular-Energy Formulas
Chloride Salt of Nicotinamide Riboside at 98% Minimum Assay from Certified Synthesis Facilities
Embodies the essence of pure, high-quality dietary supplement ingredients
NR HCL (Nicotinamide Riboside Chloride) Powder
NAD+ Precursor Cellular-Renewal Support

NR HCL
Purecium NR HCL is nicotinamide riboside chloride, the chloride salt of the NAD+ precursor nicotinamide riboside, supplied as a B2B bulk raw material for cellular-energy, healthy-aging and cognitive-wellness supplement programs. It carries CAS 23111-00-4, molecular formula C11H15ClN2O5 and molecular weight 290.70 g/mol, and is offered at 98% minimum assay by HPLC as a free-flowing crystalline powder produced by synthesis from D-ribose and nicotinamide. Vegan, allergen-free and non-irradiated, it is packed in 25 kg drums with a 25 kg minimum order and complete COA documentation.

Product name: NR HCL (Nicotinamide Riboside Chloride)
Molecular formula: C₁₁H₁₅ClN₂O₅
Starting material: D-Ribose + nicotinamide (synthesis)
Grade: Supplement grade (>=98% HPLC)
Heavy Metals: Conforms to USP/EP limits
Pesticide residue: Conforms to USP/EP limits
Packing size: 25kg/drum
CAS#: 23111-00-4
Molecular weight: 290.70 g/mol
Source: Chemical synthesis (D-ribose + nicotinamide); China
Specification: NR HCL >=98% by HPLC; free-flowing crystalline powder
Country of origin: China
Residual solvent: Conforms to USP/EP limits
Allergen free/Gluten-free/Non-GMO/Vegan/Non-Irradiation:

NR HCL Overview

NR HCL is nicotinamide riboside chloride, the chloride salt of nicotinamide riboside (NR), a form of vitamin B3 that functions as a precursor of nicotinamide adenine dinucleotide (NAD+). The compound carries CAS 23111-00-4, molecular formula C11H15ClN2O5 and molecular weight 290.70 g/mol, and the free cationic riboside is registered under CAS 1341-23-7.

For the dietary-supplement industry, NR is used in cellular-energy, healthy-aging and cognitive products, where its NAD+-precursor activity is the scientific anchor and a substantial body of published clinical research has examined NR's effects on NAD+ levels in humans. Purecium supplies NR HCL as a B2B raw material at 98% minimum assay by HPLC for distributors, contract manufacturers, private-label producers and finished supplement brands.

Source & Ingredient Identity

Purecium NR HCL is produced by controlled synthesis from D-ribose and nicotinamide, the two building blocks that are enzymatically and chemically coupled to form the riboside, followed by conversion to the chloride salt, purification, crystallization and drying. This route delivers a defined single-molecule salt with reproducible quality at commercial scale.

The declared product is nicotinamide riboside chloride, also written NR-HCl or 1-(beta-D-ribofuranosyl)nicotinamide chloride, with CAS 23111-00-4, formula C11H15ClN2O5 and molecular weight 290.70 g/mol. It is a white to off-white, free-flowing crystalline powder with good water solubility, and buyers should confirm the assay, residual nicotinamide and related-substance profile on the specification sheet.

Key Characteristics of NR HCL

1. Defined riboside salt with clinically studied NAD+ precursor activity. NR (CAS 1341-23-7 as the cation) is a B3-vitamer that enters cells and is converted to NMN and then NAD+, and its chloride salt (23111-00-4, C11H15ClN2O5, 290.70 g/mol) is the standard commercial form. Published clinical studies have examined NR supplementation and NAD+ levels, making it one of the most researched NAD+ precursors.

2. Strict quality control on a high-value active. Commercial NR HCL is specified by HPLC assay of at least 98%, residual nicotinamide, related impurities, chloride content, residual solvents, heavy metals and microbiology. Identity is confirmed against certified reference standards, giving formulators a reproducible active for precise dosing in premium products.

3. Practical physical and formulation profile. NR HCL is a white, free-flowing crystalline powder with good water solubility and low hygroscopicity compared with some other NAD+ precursors, which suits capsules, tablets, stick-packs and some beverage applications. It should be stored sealed in a cool, dry place and handled with standard dust control.

NR HCL Manufacturing

NR HCL is manufactured by a controlled synthetic route from D-ribose and nicotinamide: the ribose is activated and coupled to nicotinamide to form the riboside, which is then converted to the hydrochloride salt and purified by chromatographic and crystallization steps. In-process checks monitor reaction completion, impurity formation and salt stoichiometry throughout the batch.

Finished lots are tested by validated HPLC for assay and related substances, with residual nicotinamide quantified as the principal process-related impurity. Additional testing covers identification, chloride content, loss on drying, residual solvents, heavy metals and microbiology, following current pharmacopeial general chapters, and results are reported on the batch Certificate of Analysis.

Applications of NR HCL

Cellular-energy and healthy-aging formulas are the primary application of NR HCL. It is frequently combined with other NAD+ and mitochondrial ingredients such as NMN, resveratrol and PQQ in longevity and energy products, and its clinically studied NAD+-supporting profile is a strong label and marketing asset for premium cellular-health programs.

Cognitive-wellness and sports-nutrition products form the second cluster, using NR for mental energy, cellular resilience and recovery positioning. Formulators should verify the regulatory framework for each market: in the United States NR is used within the FDA dietary-supplement framework as a B3 vitamer, while in the European Union NR has received novel-food authorization under defined conditions, so the current status of each destination market should be confirmed before launch.

Manufacturing & Quality Control

Purecium NR HCL is produced in facilities operating under ISO 9001 and FSSC 22000 certified quality systems, with Kosher and Halal certification available. Every lot is tested for identity, HPLC assay of at least 98%, residual nicotinamide and related impurities, chloride content, loss on drying, residual solvents, heavy metals and microbiology.

Each commercial lot is traceable from raw-material intake through synthesis and purification to the finished drum, and every batch is released on a Certificate of Analysis documenting assay, impurity profile and physical data. Purecium also provides the specification sheet, SDS, allergen and gluten statements, non-GMO declarations and stability data on request.

NR HCL for B2B Supplement Manufacturing

Purecium supplies NR HCL exclusively as a B2B raw material for distributors, contract manufacturers, private-label producers and finished supplement brands. The minimum order quantity is 25 kg; NR HCL is packed in 25 kg drums with food-grade polyethylene inner bags, and samples with full documentation are available before commitment.

For North American customers, inventory is staged at Purecium's US warehouse, enabling pickup or delivery within approximately two days. Global delivery covers Hong Kong, mainland China, the EU and other regions, with export documentation prepared for every shipment, and Purecium provides specification and application guidance plus technical and regulatory communication to support formulation and registration in each destination market.

Reviewed by the Chief Quality Assurance / Regulatory Affairs Specialist at Purecium for technical accuracy and regulatory alignment.
NR HCL Frequently Asked Questions (FAQ) for B2B Buyers

Q1. What is NR HCL and how does it relate to vitamin B3?
NR HCL is nicotinamide riboside chloride (CAS 23111-00-4, C11H15ClN2O5, 290.70 g/mol), the chloride salt of nicotinamide riboside, a naturally occurring form of vitamin B3. NR is a precursor of NAD+ and is distinguished from niacin and nicotinamide by its riboside structure; the free cation is registered as CAS 1341-23-7. Purecium supplies NR HCL at 98% minimum assay by HPLC.
Q2. What purity and specification of NR HCL does Purecium supply?
Purecium supplies NR HCL at 98% minimum assay by HPLC as a white to off-white free-flowing crystalline powder. Each lot is tested for assay, residual nicotinamide, related impurities, chloride content, loss on drying, residual solvents, heavy metals and microbiology, with full results on the batch Certificate of Analysis.
Q3. How is NR HCL manufactured?
NR HCL is produced by a controlled synthetic route from D-ribose and nicotinamide: the ribose is activated and coupled to nicotinamide to form the riboside, which is converted to the hydrochloride salt and purified by chromatographic and crystallization steps. In-process checks monitor completion, impurities and salt stoichiometry, and finished lots are released by validated HPLC.
Q4. What is the difference between NR and NMN?
NR (nicotinamide riboside) and NMN (nicotinamide mononucleotide) are both NAD+ precursors but are chemically distinct: NR is the unphosphorylated riboside (supplied as the chloride salt, C11H15ClN2O5), while NMN is the phosphorylated mononucleotide (C11H15N2O8P). In the NAD+ salvage pathway NMN sits one step closer to NAD+; both are researched for supporting cellular NAD+ pools, and NR has a comparatively large body of published human clinical data.
Q5. What clinical research exists on NR and NAD+?
A substantial body of published clinical studies has examined NR supplementation in humans, reporting consistent and dose-dependent increases in blood NAD+ levels with good tolerability, along with exploratory research on metabolic and cellular-health markers. This human evidence base is one of the main reasons NR is positioned as a premium NAD+ precursor; finished-product claims must still stay within structure/function language.
Q6. What is the typical use level of NR HCL in finished supplements?
NR is typically used at doses of 100 to 300 mg per serving or per day in NAD+-support products, which is the range most frequently studied in published clinical trials. There is no established dietary reference value for NAD+ precursors, so the level should be set by the brand on the basis of the product concept and confirmed in stability and finished-product testing.
Q7. Which ingredients is NR commonly combined with?
NR is commonly formulated with NMN, resveratrol, PQQ and CoQ10 in cellular-energy and longevity stacks, and with B-complex vitamins in energy products. Because NR is a B3 vitamer, formulators should account for total B3 contribution in the formula and keep combined levels within applicable guidance, validating stability and compatibility in the finished format.
Q8. Is NR stable, and how should it be formulated?
NR HCL is a free-flowing crystalline powder with good water solubility and defined stability in dry formats. Capsules, tablets and stick-packs are the practical choices, and the powder should be stored sealed in a cool, dry place away from direct light and moisture. Finished-product stability should be confirmed with accelerated and real-time studies for the specific formula.
Q9. How is NR HCL regulated as a food ingredient?
In the United States, NR is used as a dietary-supplement ingredient within the FDA framework as a B3 vitamer, with structure/function communication only. In the European Union, nicotinamide riboside chloride has received novel-food authorization under defined specifications and conditions of use, so EU buyers should confirm the authorized form and levels. Verify the current status of each destination market before launch.
Q10. Is NR HCL suitable for vegan and allergen-free products?
Yes. NR HCL is produced by synthesis from D-ribose and nicotinamide with no animal-derived inputs, making it suitable for vegan and vegetarian formulations. It is allergen-free, gluten-free and non-GMO, and lots are non-irradiated with residual solvent and heavy-metal results conforming to USP/EP limits; these statements are documented on request.
Q11. How is NR HCL quality verified in the laboratory?
NR HCL assay is determined by validated HPLC against a certified reference standard, with residual nicotinamide and related impurities quantified in the same system. Identification is confirmed by retention and spectral match, chloride content by titration, and loss on drying, residual solvents by GC, heavy metals and microbial testing complete the release panel. Request the HPLC chromatogram on the COA.
Q12. What is the difference between the chloride salt and other salt forms of NR?
NR is a cationic molecule that is commercially supplied as a salt; the chloride salt (NR HCL) is the most widely used form in supplements and the form covered by the EU novel-food authorization. Other salt forms such as the tartrate have been used in some products, but chloride is the standard commercial grade supplied by Purecium at 98% minimum assay.
Q13. What documentation should we request when sourcing NR HCL?
Request a current specification sheet and a batch Certificate of Analysis showing HPLC assay, residual nicotinamide, related impurities, chloride content, loss on drying, residual solvents, heavy metals and microbial results, plus an SDS and allergen and gluten statements. Also request ISO 9001 and FSSC 22000 certificates, Kosher and Halal certificates where relevant, and stability data for registration files.
Q14. What is the MOQ, packing and lead time for NR HCL from Purecium?
The minimum order quantity is 25 kg, and NR HCL is packed in 25 kg drums with food-grade polyethylene inner bags. Samples and full technical documentation are available before commitment. Standard production lead time is typically 10 to 20 working days after order confirmation, with US warehouse stock enabling faster dispatch for North American customers.
Q15. Why should we source NR HCL from Purecium?
Purecium supplies NR HCL at 98% minimum HPLC purity from controlled synthesis, and every batch is released on a full Certificate of Analysis covering assay, residual nicotinamide, related impurities, residual solvents, heavy metals and microbiology. Production follows ISO 9001 and FSSC 22000 certified systems with Kosher and Halal certification available, the minimum order is 25 kg, and US warehouse inventory enables fast fulfillment.
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