Q1. What is Zinc Gluconate and what is it used for in dietary supplements?

Zinc gluconate is a water-soluble zinc salt of gluconic acid, CAS 4468-02-4, with molecular formula C12H22O14Zn, molecular weight 455.68 g/mol and approximately 14.3% elemental zinc. It is used in dietary supplements for immune support, skin, hair and nails health, antioxidant blends and lozenges or chewables. Typical servings supply 5 mg to 30 mg of elemental zinc.

Q2. How much elemental zinc does Zinc Gluconate provide and how should we dose it?

Zinc gluconate provides approximately 14.3% elemental zinc by weight, so about 70 mg of zinc gluconate delivers roughly 10 mg of elemental zinc and 210 mg delivers about 30 mg. The exact assay is stated on each batch Certificate of Analysis. Formulators use this ratio to convert compound weight into declared elemental zinc on labels.

Q3. Does Purecium's Zinc Gluconate conform to the USP monograph, and how is the assay performed?

Yes. Purecium's Zinc Gluconate is manufactured in USP grade with assay conforming to the USP monograph for zinc gluconate. The elemental zinc content is quantified by complexometric titration with EDTA or by atomic absorption spectroscopy, and gluconate identity is confirmed by compendial identification tests. Full results are reported on the batch Certificate of Analysis.

Q4. How does zinc gluconate compare with zinc citrate, zinc picolinate and zinc oxide?

Zinc gluconate and zinc citrate are both considered gentle, well-tolerated forms, zinc picolinate is a chelate with a distinct absorption profile, and zinc oxide is a low-cost, high-density form used when high zinc loads are needed in small capsules or tablets. Gluconate offers water solubility and a mild taste, which is why it is common in lozenges, chewables and powders.

Q5. Why is zinc gluconate the preferred zinc form for lozenges and chewables?

Zinc gluconate is preferred for lozenges and chewables because it is water soluble, dissolves steadily in the mouth and has a mild, less metallic taste than inorganic salts such as zinc oxide or zinc sulfate. These organoleptic properties suit slow-dissolving formats where the salt is in direct contact with the palate, and the fine powder blends cleanly into chewable bases.

Q6. What are the starting materials and manufacturing route for Zinc Gluconate?

The route starts with fermentation of glucose to gluconic acid, which is reacted with a food-grade zinc source such as zinc oxide to form zinc gluconate. The reaction solution is purified, concentrated, crystallized and dried to a white free-flowing powder. Country of origin is China, and the declared starting materials are documented on the specification sheet.

Q7. Can zinc gluconate be combined with vitamin C and vitamin D3 in immune formulas?

Yes. Zinc gluconate is very commonly paired with vitamin C and vitamin D3 in daily immune-support tablets, effervescents and powders, and the combination is a standard architecture in finished immune ranges. Formulators should verify ingredient compatibility in their chosen matrix and keep total elemental zinc within label targets, typically 5 mg to 30 mg per serving.

Q8. Is Purecium's Zinc Gluconate vegan, non-GMO, gluten-free and allergen-free?

Yes. Because the gluconic acid is produced by glucose fermentation and the zinc source is a food-grade inorganic material, no animal-derived inputs, carriers or processing aids are used. The product is therefore suitable for vegan formulations and carries non-GMO, gluten-free, allergen-free and non-irradiated statements on its specification and certificates.

Q9. What documentation should we request when sourcing zinc gluconate for registration?

Request a current specification sheet, a batch-specific Certificate of Analysis showing identification, elemental zinc assay, heavy metals, residual solvent and microbial results, an SDS, allergen and gluten statements, and non-GMO and vegan declarations. For regulatory filings, also request ISO 9001 and FSSC 22000 certificates, flow diagrams and stability data.

Q10. What are the main finished-product applications for zinc gluconate powder?

The main applications are immune-support formulas, often paired with vitamin C and vitamin D3; skin, hair and nails products; antioxidant blends; and lozenges or chewables. Typical supplement servings supply 5 mg to 30 mg of elemental zinc per day. The fine powder suits capsules, tablets, effervescents, chewables, stick-packs and premixes.

Q11. How should zinc gluconate be stored and what is its shelf life?

Store in tightly sealed original drums in a cool, dry place below 25 degrees Celsius, protected from moisture, heat and direct sunlight. Zinc gluconate is stable under these conditions, and shelf life is generally 36 months from the date of manufacture. Each shipment's Certificate of Analysis states the production and expiry dates for inventory planning.

Q12. What is the MOQ, packing and lead time for Zinc Gluconate from Purecium?

The minimum order quantity is 25 kg, and the product is packed in 25 kg drums with food-grade polyethylene inner bags. Samples and technical documentation are available before commitment. Standard production lead time is typically 7 to 15 working days after order confirmation. For North American customers, inventory is staged at Purecium's US warehouse with pickup or delivery within about two days.

Q13. How are heavy metals, residual solvents and pesticide residues controlled?

Every batch is tested for heavy metals, residual solvents and pesticide residues against USP and EP limits before release, alongside identification, elemental zinc assay, loss on drying and microbial purity. Because the gluconic acid is produced by fermentation, purification steps are designed to remove process and fermentation impurities. Results are reported on the batch Certificate of Analysis.

Q14. How do we calculate the elemental zinc content for label declarations?

Multiply the zinc gluconate weight by approximately 0.143, the elemental zinc fraction, to obtain elemental zinc. For example, 140 mg of zinc gluconate supplies about 20 mg of elemental zinc. Use the batch-specific assay from the Certificate of Analysis for the most accurate calculation, since actual assay may vary slightly around the nominal 14.3%.

Q15. Why should we source Zinc Gluconate from Purecium?

Purecium supplies Zinc Gluconate with every batch released on a full Certificate of Analysis covering identity, elemental zinc assay, heavy metals, residual solvent and microbial results, plus specification, SDS and supporting statements. Production follows ISO 9001 and FSSC 22000 certified systems. The MOQ is 25 kg, US warehouse inventory enables fast fulfillment, global delivery covers Hong Kong, mainland China and the EU, and buyers receive direct technical and regulatory support.

Zinc Gluconate USP Powder for Immune & Skin Formulas

Zinc Gluconate USP Powder for Immune, Skin and Antioxidant Supplement Formulas
Water-Soluble Zinc Salt Produced in ISO 9001 and FSSC 22000 Certified Facilities
Embodies the essence of pure, high-quality dietary supplement ingredients
Zinc Gluconate Powder (USP)
Low-Irritant, Highly Soluble Zinc Salt

Zinc Gluconate
Zinc Gluconate is a water-soluble zinc salt of gluconic acid, CAS 4468-02-4, with molecular formula C12H22O14Zn, molecular weight 455.68 g/mol and approximately 14.3% elemental zinc. Produced by reaction of gluconic acid from glucose fermentation with a food-grade zinc source, it is a white free-flowing crystalline powder in USP grade. It is allergen-free, gluten-free, non-GMO, vegan and non-irradiated, packed in 25 kg drums with a 25 kg MOQ and full B2B documentation including CoA. It suits immune, skin, hair and nails and antioxidant formulas, with typical servings of 5 mg to 30 mg elemental zinc.

Product name: Zinc Gluconate
Molecular formula: C₁₂H₂₂O₁₄Zn
Starting material: Gluconic acid + food-grade zinc source
Grade: Food Grade (USP/FCC)
Heavy Metals: Conforms to USP/EP limits
Pesticide residue: Conforms to USP/EP limits
Packing size: 25kg/drum
CAS#: 4468-02-4
Molecular weight: 455.68 g/mol
Source: Synthetic (gluconic acid + zinc salt reaction)
Specification: Zinc gluconate USP; Zn approx. 14.3%
Country of origin: China
Residual solvent: Conforms to USP/EP limits
Allergen free/Gluten-free/Non-GMO/Vegan/Non-Irradiation:

Zinc Gluconate Overview

Zinc gluconate is a water-soluble zinc salt of gluconic acid, widely used in dietary supplements for immune support, skin, hair and nail health, and antioxidant formulations. It carries CAS number 4468-02-4, molecular formula C12H22O14Zn and molecular weight 455.68 g/mol, and provides approximately 14.3% elemental zinc. Purecium supplies Zinc Gluconate as a B2B raw material to supplement manufacturers, formulators and private-label producers.

Zinc is an essential trace mineral that supports immune function, DNA synthesis, cell division and protein synthesis, and zinc deficiency is among the most widespread mineral shortfalls worldwide, which is why zinc salts are staples of daily wellness and immune-support ranges. The NIH Office of Dietary Supplements maintains a Zinc fact sheet documenting these physiological roles, and EFSA has authorized health claims for zinc covering normal function of the immune system, DNA synthesis and protection of cells from oxidative stress.

Source & Ingredient Identity

Purecium Zinc Gluconate is made by reacting gluconic acid with a food-grade zinc source such as zinc oxide under controlled conditions, followed by crystallization, drying and milling. The gluconic acid itself is produced by fermentation of glucose, which makes the entire route traceable from fermentable carbohydrate through to the finished zinc salt.

For B2B purchasing, the identity checks are the CAS number 4468-02-4, molecular formula C12H22O14Zn and molecular weight 455.68 g/mol, together with the gluconate and zinc identification tests in the current USP monograph for zinc gluconate. Buyers should also confirm the elemental zinc specification, which Purecium states as approximately 14.3%, and request the declared starting materials and country of origin on the specification sheet.

Key Characteristics of Zinc Gluconate

1. High, consistent elemental zinc value. Purecium Zinc Gluconate provides approximately 14.3% elemental zinc by weight, calculated from the molecular formula C12H22O14Zn. The assay is confirmed on every batch and reported on the Certificate of Analysis, so formulators can convert between compound weight and elemental zinc with confidence.

2. White, water-soluble crystalline powder. The product is a white free-flowing crystalline or granular powder with good water solubility, which makes it easy to dose, blend and process in tableting and encapsulation lines, and it has the characteristically mild taste of gluconate zinc forms used in chewable and lozenge products.

3. Clean-label, non-GMO and allergen-free profile. Zinc gluconate is free from gluten, common allergens and irradiation, and it is non-GMO and suitable for vegan formulations because no animal-derived materials are used in its production. These attributes support clean-label positioning in immune, beauty-from-within and daily-mineral ranges.

Zinc Gluconate Manufacturing

Production starts with fermentation of glucose to gluconic acid, which is then reacted with a food-grade zinc source such as zinc oxide to form Zinc Gluconate. The solution is purified, concentrated, crystallized and dried to yield the white free-flowing powder, with in-process checks on reaction completion, pH, moisture and particle size at every stage.

Finished lots are tested for identification of zinc and gluconate, elemental zinc assay, loss on drying, heavy metals, residual solvents, pesticide residues and microbial limits, and the results are compiled into the batch Certificate of Analysis. Each lot is traceable from starting glucose and zinc materials through to the finished drum, supporting complete supply-chain documentation.

Applications of Zinc Gluconate

Immune-support formulas are the leading application of zinc gluconate, and it is commonly paired with vitamin C and vitamin D3 in daily immunity blends, effervescent tablets and powder sachets. The pairing is well established in finished-product formulation, and the NIH Office of Dietary Supplements recognizes zinc's role in normal immune function while EFSA has authorized health claims for zinc covering normal function of the immune system.

Skin, hair and nails products form the second cluster, alongside antioxidant blends where zinc contributes to protection of cells from oxidative stress. EFSA has authorized health claims for zinc covering maintenance of normal skin, hair and nails, normal cognitive function, and normal vision, and the NIH Office of Dietary Supplements documents zinc's wider physiological roles in its Zinc fact sheet.

Lozenges and chewables are a third application where the mild taste and mouth-friendly character of zinc gluconate are advantages, and typical supplement servings across these formats supply 5 mg to 30 mg of elemental zinc per day. Formulators calculate label doses from the approximately 14.3% elemental content, for example roughly 70 mg of zinc gluconate provides about 10 mg of elemental zinc.

Manufacturing & Quality Control

Zinc Gluconate is produced in facilities operating under ISO 9001 and FSSC 22000 certified quality and food-safety systems, with Kosher and Halal certification available for the product. The zinc assay is verified by methods aligned with current compendial practice, including complexometric titration, and gluconate identity is confirmed alongside the elemental zinc result.

Analytical methods follow the current USP-NF monograph approach for Zinc Gluconate, and release testing covers identity, assay, loss on drying, heavy metals, residual solvents, pesticide residues and microbial purity against USP and EP limits. Every batch is released only when all parameters are within specification, with the full data set provided on the batch Certificate of Analysis.

Zinc Gluconate for B2B Supplement Manufacturing

Purecium supplies Zinc Gluconate exclusively as a B2B raw material for distributors, contract manufacturers, private-label producers and finished supplement brands. The minimum order quantity is 25 kg, the product is packed in 25 kg drums with food-grade polyethylene inner bags, and samples plus full technical documentation, including batch Certificate of Analysis and complete batch traceability, are available before any commitment.

For North American customers, inventory is staged at Purecium's US warehouse, enabling pickup or delivery within approximately two days, and global delivery covers Hong Kong, mainland China, the EU and other regions with export documentation prepared for each shipment. Purecium supports formulation with elemental-zinc calculation guidance, specification and stability data, and direct technical and regulatory communication.

Reviewed by the Chief Quality Assurance / Regulatory Affairs Specialist at Purecium for technical accuracy and regulatory alignment.
Zinc Gluconate Frequently Asked Questions (FAQ) for B2B Buyers

Q1. What is Zinc Gluconate and what is it used for in dietary supplements?
Zinc gluconate is a water-soluble zinc salt of gluconic acid, CAS 4468-02-4, with molecular formula C12H22O14Zn, molecular weight 455.68 g/mol and approximately 14.3% elemental zinc. It is used in dietary supplements for immune support, skin, hair and nails health, antioxidant blends and lozenges or chewables. Typical servings supply 5 mg to 30 mg of elemental zinc.
Q2. How much elemental zinc does Zinc Gluconate provide and how should we dose it?
Zinc gluconate provides approximately 14.3% elemental zinc by weight, so about 70 mg of zinc gluconate delivers roughly 10 mg of elemental zinc and 210 mg delivers about 30 mg. The exact assay is stated on each batch Certificate of Analysis. Formulators use this ratio to convert compound weight into declared elemental zinc on labels.
Q3. Does Purecium's Zinc Gluconate conform to the USP monograph, and how is the assay performed?
Yes. Purecium's Zinc Gluconate is manufactured in USP grade with assay conforming to the USP monograph for zinc gluconate. The elemental zinc content is quantified by complexometric titration with EDTA or by atomic absorption spectroscopy, and gluconate identity is confirmed by compendial identification tests. Full results are reported on the batch Certificate of Analysis.
Q4. How does zinc gluconate compare with zinc citrate, zinc picolinate and zinc oxide?
Zinc gluconate and zinc citrate are both considered gentle, well-tolerated forms, zinc picolinate is a chelate with a distinct absorption profile, and zinc oxide is a low-cost, high-density form used when high zinc loads are needed in small capsules or tablets. Gluconate offers water solubility and a mild taste, which is why it is common in lozenges, chewables and powders.
Q5. Why is zinc gluconate the preferred zinc form for lozenges and chewables?
Zinc gluconate is preferred for lozenges and chewables because it is water soluble, dissolves steadily in the mouth and has a mild, less metallic taste than inorganic salts such as zinc oxide or zinc sulfate. These organoleptic properties suit slow-dissolving formats where the salt is in direct contact with the palate, and the fine powder blends cleanly into chewable bases.
Q6. What are the starting materials and manufacturing route for Zinc Gluconate?
The route starts with fermentation of glucose to gluconic acid, which is reacted with a food-grade zinc source such as zinc oxide to form zinc gluconate. The reaction solution is purified, concentrated, crystallized and dried to a white free-flowing powder. Country of origin is China, and the declared starting materials are documented on the specification sheet.
Q7. Can zinc gluconate be combined with vitamin C and vitamin D3 in immune formulas?
Yes. Zinc gluconate is very commonly paired with vitamin C and vitamin D3 in daily immune-support tablets, effervescents and powders, and the combination is a standard architecture in finished immune ranges. Formulators should verify ingredient compatibility in their chosen matrix and keep total elemental zinc within label targets, typically 5 mg to 30 mg per serving.
Q8. Is Purecium's Zinc Gluconate vegan, non-GMO, gluten-free and allergen-free?
Yes. Because the gluconic acid is produced by glucose fermentation and the zinc source is a food-grade inorganic material, no animal-derived inputs, carriers or processing aids are used. The product is therefore suitable for vegan formulations and carries non-GMO, gluten-free, allergen-free and non-irradiated statements on its specification and certificates.
Q9. What documentation should we request when sourcing zinc gluconate for registration?
Request a current specification sheet, a batch-specific Certificate of Analysis showing identification, elemental zinc assay, heavy metals, residual solvent and microbial results, an SDS, allergen and gluten statements, and non-GMO and vegan declarations. For regulatory filings, also request ISO 9001 and FSSC 22000 certificates, flow diagrams and stability data.
Q10. What are the main finished-product applications for zinc gluconate powder?
The main applications are immune-support formulas, often paired with vitamin C and vitamin D3; skin, hair and nails products; antioxidant blends; and lozenges or chewables. Typical supplement servings supply 5 mg to 30 mg of elemental zinc per day. The fine powder suits capsules, tablets, effervescents, chewables, stick-packs and premixes.
Q11. How should zinc gluconate be stored and what is its shelf life?
Store in tightly sealed original drums in a cool, dry place below 25 degrees Celsius, protected from moisture, heat and direct sunlight. Zinc gluconate is stable under these conditions, and shelf life is generally 36 months from the date of manufacture. Each shipment's Certificate of Analysis states the production and expiry dates for inventory planning.
Q12. What is the MOQ, packing and lead time for Zinc Gluconate from Purecium?
The minimum order quantity is 25 kg, and the product is packed in 25 kg drums with food-grade polyethylene inner bags. Samples and technical documentation are available before commitment. Standard production lead time is typically 7 to 15 working days after order confirmation. For North American customers, inventory is staged at Purecium's US warehouse with pickup or delivery within about two days.
Q13. How are heavy metals, residual solvents and pesticide residues controlled?
Every batch is tested for heavy metals, residual solvents and pesticide residues against USP and EP limits before release, alongside identification, elemental zinc assay, loss on drying and microbial purity. Because the gluconic acid is produced by fermentation, purification steps are designed to remove process and fermentation impurities. Results are reported on the batch Certificate of Analysis.
Q14. How do we calculate the elemental zinc content for label declarations?
Multiply the zinc gluconate weight by approximately 0.143, the elemental zinc fraction, to obtain elemental zinc. For example, 140 mg of zinc gluconate supplies about 20 mg of elemental zinc. Use the batch-specific assay from the Certificate of Analysis for the most accurate calculation, since actual assay may vary slightly around the nominal 14.3%.
Q15. Why should we source Zinc Gluconate from Purecium?
Purecium supplies Zinc Gluconate with every batch released on a full Certificate of Analysis covering identity, elemental zinc assay, heavy metals, residual solvent and microbial results, plus specification, SDS and supporting statements. Production follows ISO 9001 and FSSC 22000 certified systems. The MOQ is 25 kg, US warehouse inventory enables fast fulfillment, global delivery covers Hong Kong, mainland China and the EU, and buyers receive direct technical and regulatory support.
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